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Information Journal Paper

Title

EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE

Pages

  198-204

Abstract

 Elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. H2-receptor antagonists have potential oxygen radical scavenging properties. We tried to determine the effects of two H2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (LPO) and lipid profile (LP) in plasma and liver of ?-irradiated (1Gy/day for 3 days) BALB/c mice. The control group of mice were fed with normal food and drinks but the experiment group of mice were fed control diet and drinking water, containing cimetidine or ranitidine (1mg/lit). After 3 days of supplementation, the animals were subjected to sublethal ?-radiation, which caused a significant increase in cholesterol level in experimental group (100% increase in comparison with the control group), but the amount of phospholipids did not change. The ratio of cholesterol to phospholipid showed a slight increase. Also ?-irradiation caused a significant increase in lipid fluorescence (11-48%), conjugated dienes (33-81%) in liver and increase in malondialdehyde (19-300%) in serum of mice who had received 1.09-3.1 Gy for 1-3 days. Cimetidine or ranitidine supplementation was able to restore the changes of LPO and LP in mice (1 Gy-radiated for 3 days). It is therefore concluded that the mice treated with cimetidine or ranitidine were able to tolerate biomembrane damages provoked by sublethal ?-radiation. This supports the hypothesis that cimetidine or ranitidine may afford an efficient protection against ionizing radiation or diseases that are characterized by in vivo free radical-mediated oxidative stress mechanisms.

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    Cite

    APA: Copy

    KABOUDANIAN ARDESTANI, S., MAHMOOD JANLOW, M., KARIMINIA, AMINA, & TAVAKOLI, Z.. (2004). EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE. ACTA MEDICA IRANICA, 42(3), 198-204. SID. https://sid.ir/paper/277596/en

    Vancouver: Copy

    KABOUDANIAN ARDESTANI S., MAHMOOD JANLOW M., KARIMINIA AMINA, TAVAKOLI Z.. EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE. ACTA MEDICA IRANICA[Internet]. 2004;42(3):198-204. Available from: https://sid.ir/paper/277596/en

    IEEE: Copy

    S. KABOUDANIAN ARDESTANI, M. MAHMOOD JANLOW, AMINA KARIMINIA, and Z. TAVAKOLI, “EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE,” ACTA MEDICA IRANICA, vol. 42, no. 3, pp. 198–204, 2004, [Online]. Available: https://sid.ir/paper/277596/en

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