CORRELATION BETWEEN DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) & CORONARY ARTERY DISEASE: A FACT OR FICTION?

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AMINIAN B.; OSTOVAN M.A.; OMRANI GH.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2000 | Volume:2 | Issue:2 (SN 6) Page(s): 107-111

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Title

CORRELATION BETWEEN DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) & CORONARY ARTERY DISEASE: A FACT OR FICTION?

Author(s)

AMINIAN B. | OSTOVAN M.A. | OMRANI GH. | Issue Writer Certificate

Keywords

DEHYDROEPIANDROSTERONE SULFATEQ4

CORONARY ARTERY DISEASEQ3

CHOLESTEROLQ3

MYOCARDIAL INFARCTIONQ2

Abstract

Dehydroepiandrosterone (DHEA) or its sulfate derivative (DHEA-S) is the major C19 steroid hormone secreted by adrenal cortex. It has been claimed that it has an inverse correlation with atherogenesis through its antiproliferative effect. But this correlation is a matter of controversy. The aim of this study was to examine the effect of DHEA-S on CORONARY ARTERY DISEASE (CAD). In a prospective randomized study, 202 patients with possible CAD who underwent coronary angiography between January 1999 and June 1999 were studied. They were allocated into two groups, group 1 (n=142 Female: 39, Male: 103) had more than 75 percent cross-sectional area narrowing of at least one coronary artery, and group 2 (n=60 Female: 28,Male: 32) had no CORONARY ARTERY DISEASE. The age range was 18-75 years, and it was matched between the two groups. Level of DHEA-S (measured by two different methods ELISA and RIA), fasting blood sugar, full lipid profile (TG, total CHOLESTEROL, LDL-C, HDL-C) were measured in the two groups. Other major coronary risk factors were also compared between the two groups. The level of DHEA-S had an inverse linear correlation with age (r = -0.34 and P<0.01). There was no statistically significant correlation between the level of DHEA-S and CORONARY ARTERY DISEASE in different age groups in males and females. Likewise, there was no statistically significant correlation between the level of DHEA-S and blood sugar (P=0.08), HDL (P=0.41), LDL (P=0.09), body mass index (P=0.4), hypertension and current smoking. The present study doesn’t confirm the inverse correlation between DHEA-S and CORONARY ARTERY DISEASE.

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APA: Copy

AMINIAN, B., OSTOVAN, M.A., & OMRANI, GH.. (2000). CORRELATION BETWEEN DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) & CORONARY ARTERY DISEASE: A FACT OR FICTION? . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 2(2 (SN 6)), 107-111. SID. https://sid.ir/paper/27794/en

Vancouver: Copy

AMINIAN B., OSTOVAN M.A., OMRANI GH.. CORRELATION BETWEEN DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) & CORONARY ARTERY DISEASE: A FACT OR FICTION? . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2000;2(2 (SN 6)):107-111. Available from: https://sid.ir/paper/27794/en

IEEE: Copy

B. AMINIAN, M.A. OSTOVAN, and GH. OMRANI, “CORRELATION BETWEEN DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) & CORONARY ARTERY DISEASE: A FACT OR FICTION? ,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 2, no. 2 (SN 6), pp. 107–111, 2000, [Online]. Available: https://sid.ir/paper/27794/en

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