CORRELATION BETWEEN B#HCG LEVEL AND THYROID FUNCTION TESTS IN MOLAR PREGNANCY

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SALAVATIAN F.; AMINIAN B.; OMRANI GH.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2000 | Volume:2 | Issue:2 (SN 6) Page(s): 87-91

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Title

CORRELATION BETWEEN B#HCG LEVEL AND THYROID FUNCTION TESTS IN MOLAR PREGNANCY

Author(s)

SALAVATIAN F. | AMINIAN B. | OMRANI GH. | Issue Writer Certificate

Keywords

HUMAN CHORIONIC GONADOTROPINQ4

HYDATIDIFORM MOLEQ4

THYROID FUNCTION TESTSQ4

Abstract

In view of controversy regarding the role of HUMAN CHORIONIC GONADOTROPIN (hCG) as the stimulator of thyroid function in patients with trophoblastic tumors, especially HYDATIDIFORM MOLE, we conducted a study to explore whether a correlation between HUMAN CHORIONIC GONADOTROPIN and thyroid function is demonstrable in such patients. Forty-eight patients with HYDATIDIFORM MOLE, who had a drop in serum βhCG concentration below 5 mIU/ml during a period of eighteen months after evacuation, were selected. Serum βhCG, total T3, total T4 and serum TSH were measured both when βhCG was high and when it dropped to below 5 mIU/ml. Serum βhCG, total T3, and total T4 were measured with radioimmunoassay. The human TSH-coated tube assay was utilized for immunoradiometric assay of TSH. Among forty-three patients with βhCG concentrations exceeding 100 mIU/ml, total T4 values were higher than 8.8 βg/dl in thirty patients. The regression equation between total T4 and high βhCG levels was 6.36 with a P value of 0.00. The regression equation between FT4I and high βhCG level was 2.105 (P=0.002). The regression equation between high T3 and FT3I and high levels of βhCG was 133.39 and 37.3 respectively (P=0.026 and 0.024). The mean value of TSH was 0.9915 mIU/ml before and 1.533 mIU/ml after treatment. The regression equation between TSH and βhCG was 1.8448 (P=0.044). This study shows a strong correlation between high serum βhCG and total serum T4 and FT4I. There is also a correlation between high serum βhCG and total T3 and FT3I. There is a weak statistical correlation between high serum βhCG and low serum TSH.

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APA: Copy

SALAVATIAN, F., AMINIAN, B., & OMRANI, GH.. (2000). CORRELATION BETWEEN B#HCG LEVEL AND THYROID FUNCTION TESTS IN MOLAR PREGNANCY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 2(2 (SN 6)), 87-91. SID. https://sid.ir/paper/27795/en

Vancouver: Copy

SALAVATIAN F., AMINIAN B., OMRANI GH.. CORRELATION BETWEEN B#HCG LEVEL AND THYROID FUNCTION TESTS IN MOLAR PREGNANCY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2000;2(2 (SN 6)):87-91. Available from: https://sid.ir/paper/27795/en

IEEE: Copy

F. SALAVATIAN, B. AMINIAN, and GH. OMRANI, “CORRELATION BETWEEN B#HCG LEVEL AND THYROID FUNCTION TESTS IN MOLAR PREGNANCY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 2, no. 2 (SN 6), pp. 87–91, 2000, [Online]. Available: https://sid.ir/paper/27795/en

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