ASSOCIATION BETWEEN B3 
ADRENOCEPTOR GENE POLYMORPHISM AND OBESITY: TEHRAN LIPID AND GLUCOSE STUDY

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ESHRAGHI P.; HEDAYATI MAHDI; DANESHPOUR M.A.S.; MIRMIRAN PARVIN; AZIZI FEREYDOUN

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2005 | Volume:7 | Issue:SUPPLEMENT 4 Page(s): 393-398

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Title

ASSOCIATION BETWEEN B3 ADRENOCEPTOR GENE POLYMORPHISM AND OBESITY: TEHRAN LIPID AND GLUCOSE STUDY

Author(s)

Keywords

OBESITYQ2

BQ3

SANS-SERIF">3Q2

SANS-SERIF"> ADRENOCEPTORQ4

BMIQ4

POLYMORPHISMQ4

Abstract

Introduction: The b3-Adenoceptor (ADRB3) is one of the genes, which play a role in the regulation of lipid metabolism, especially in OBESITY. In the other studies a common ADRB3 POLYMORPHISM (Trp64Arg) shows the association to OBESITY. In this study we want to examine this finding in an Iranian population. Materials and Methods: Subjects were selected from the Tehran Lipid and Glucose Study in four groups according to their body mass index: BMI<20, 20£BMI<25, 25£BMI<30, BMI³30 and finally 431 (211 men and 220 women) subjects were randomly selected for each group. We measured FBS, HDL-C, triglyceride and cholesterol level and accounted for factors that are known to influence on OBESITY, such as smoking, body mass index, Ideal body weight and blood pressure. We amplified a segment of the mentioned gene with PCR and then revealed the POLYMORPHISM with RFLP (BSTN1).Results: The A allele frequency was 0.08 among the population and its presence was significantly associated with increase of BMI (AA/TA, 27±5.6 kg/m2; TT, 25.4±5.5 kg/m2; P:0.041) and other related factors such as FBS, triglyceride and cholesterol levels and the decrease of the ideal body weight. Conclusion: These data demonstrate that the (Trp64Arg) variation at the b3-Adenoceptor gene locus has an association with increase of body mass index and decrease of ideal body weight in this population.

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APA: Copy

ESHRAGHI, P., HEDAYATI, MAHDI, DANESHPOUR, M.A.S., MIRMIRAN, PARVIN, & AZIZI, FEREYDOUN. (2005). ASSOCIATION BETWEEN B₃ ADRENOCEPTOR GENE POLYMORPHISM AND OBESITY: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(SUPPLEMENT 4), 393-398. SID. https://sid.ir/paper/27801/en

Vancouver: Copy

ESHRAGHI P., HEDAYATI MAHDI, DANESHPOUR M.A.S., MIRMIRAN PARVIN, AZIZI FEREYDOUN. ASSOCIATION BETWEEN B₃ ADRENOCEPTOR GENE POLYMORPHISM AND OBESITY: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(SUPPLEMENT 4):393-398. Available from: https://sid.ir/paper/27801/en

IEEE: Copy

P. ESHRAGHI, MAHDI HEDAYATI, M.A.S. DANESHPOUR, PARVIN MIRMIRAN, and FEREYDOUN AZIZI, “ASSOCIATION BETWEEN B₃ ADRENOCEPTOR GENE POLYMORPHISM AND OBESITY: TEHRAN LIPID AND GLUCOSE STUDY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. SUPPLEMENT 4, pp. 393–398, 2005, [Online]. Available: https://sid.ir/paper/27801/en

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