VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS

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NAMAYANDEH S.M.; EMAMI MEYBODI M.; SADR BAFGHI S.M.H.; YEGANEH FARD S.; KAMRAN M.; MOTAFAKER M.

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2007 | Volume:45 | Issue:4 Page(s): 277-281

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Title

VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS

Author(s)

Keywords

VITAMIN E

LOVASTATIN

HYPERCHOLESTROLEMIA

HDL-CHOLESTROL

Abstract

HDL can prevent LDL-c oxidation. The low HDL-c State also may benefit clinically from supplemented antioxidant. This study was designed to evaluate the combination therapy of statin and VITAMIN E in hypercholesterolemic patients. The patients were randomized in a clinical trial aimed to avaluate the effect of VITAMIN E and/or statin. The life style of patients didn’t alter during intervention. The subjects were randomized to two treatment groups A and B: (1) LOVASTATIN 20mg daily at bedtime. (group A); (2) VITAMIN E 400 iu daily plus LOVASTATIN 20mg daily (group B). The lipid values of each patients at baseline and after 8 weeks of treatment were compared by paired t test. The mean baseline lipid levels for 60 subjects were as follows: plasma cholesterol, triglyceride, LDL-c and HDL-c 285±68, 268±121, 158±32, 49±11 mg/dl respectively. Serum lipid levels changes in group A (statin only) and in group B (statin and VITAMIN E) were statistically significant. In comparison of lipid profiles changes between two groups we observed that HDL-c changes in group B were significantly lower than in group A. VITAMIN E supplement blocks the respons of HDL-c to LOVASTATIN therapy in hypercholestrolemic patients.

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APA: Copy

NAMAYANDEH, S.M., EMAMI MEYBODI, M., SADR BAFGHI, S.M.H., YEGANEH FARD, S., KAMRAN, M., & MOTAFAKER, M.. (2007). VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS. ACTA MEDICA IRANICA, 45(4), 277-281. SID. https://sid.ir/paper/278032/en

Vancouver: Copy

NAMAYANDEH S.M., EMAMI MEYBODI M., SADR BAFGHI S.M.H., YEGANEH FARD S., KAMRAN M., MOTAFAKER M.. VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS. ACTA MEDICA IRANICA[Internet]. 2007;45(4):277-281. Available from: https://sid.ir/paper/278032/en

IEEE: Copy

S.M. NAMAYANDEH, M. EMAMI MEYBODI, S.M.H. SADR BAFGHI, S. YEGANEH FARD, M. KAMRAN, and M. MOTAFAKER, “VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS,” ACTA MEDICA IRANICA, vol. 45, no. 4, pp. 277–281, 2007, [Online]. Available: https://sid.ir/paper/278032/en

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