FACTORS INFLUENCING 2-H POSTCHALLENGE PLASMA GLUCOSE AND ISOLATED POSTCHALLENGE HYPERGLYCEMIA; TEHRAN LIPID AND GLUCOSE STUDY (TLGS)

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HOSSEINPANAH F.; GHAFARI HAMED REZA; RAMBOD M.; AZIZI FEREYDOUN

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2005 | Volume:7 | Issue:SUPPLEMENT 4 Page(s): 405-414

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Title

FACTORS INFLUENCING 2-H POSTCHALLENGE PLASMA GLUCOSE AND ISOLATED POSTCHALLENGE HYPERGLYCEMIA; TEHRAN LIPID AND GLUCOSE STUDY (TLGS)

Author(s)

HOSSEINPANAH F. | GHAFARI HAMED REZA | RAMBOD M. | AZIZI FEREYDOUN | Issue Writer Certificate

Keywords

DIABETESQ3

2 HOUR POSTLOAD GLUCOSEQ3

GLUCOSE TOLERANCE TESTQ4

Abstract

Introduction: To determine the factors influencing the value of 2 hour plasma glucose (2h-PG) during oral glucose challenge test (OGTT) and to determine factors predicting isolated postchallenge hyperglycemia [(IPH) (FPG < 126 mg/dL and 2h-PG ³200 mg/dL)] in a population based study. Materials and Methods: From 15,005 participants the Tehran lipid and glucose study (TLGS),we evaluated data and result of OGTT in 5,386 individuals (2,909 women and 2,437 men) aged ³20 years, free of known DIABETES and other disorders influencing glucose metabolism. Multiple linear and a logistic regression models were developed to predict the value of 2h-PG and IPH respectively. Results: The multiple linear regression model showed six explanatory factors (FPG, age, sex, TG, SBP, waist) to be positively correlated with 2h-PG. The model could predict 47.7% of total variance of 2h-PG. The percent contributions of the above mentioned variables were 41.7, 2.2, 1.7, 1.2, 0.7 and 0.2, respectively. The overall prevalences of non-diabetic subjects, IPH and undiagnosed type 2 DM (FPG³126 mg/dL) were 94.5% (n=5,088), 2.5% (n=133) and 3.1% (n=165) respectively. The odds ratios for presence of IPH were statistically significant for each 5 mg/dl increment of FPG (OR=1.95; 95% CI: 1.8-2.1), age ³40 years (OR=2.0; 95% CI: 1.3-3.2), abnormal waist (OR=2.1, 95% CI: 1.4-3.1) and abnormal TG (OR=2.0; 95% CI: 1.3-3.1). Conclusion: Age, sex, TG, SBP and waist after FPG are the best predictors of 2h-PG. Considering the logistic analysis, OGTT can be recommended in subjects with FPG <126 mg/dL in the presence of abnormal waist circumference and TG, age ³40 and especially when FPG reaches values close to 126 mg/dL.

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References

COMPARISON OF ADA AND WHO CRITERIA IN DETECTING GLUCOSE DISORDERS IN A POPULATION-BASED STUDY: TEHRAN LIPID AND GLUCOSE STUDY

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APA: Copy

HOSSEINPANAH, F., GHAFARI, HAMED REZA, RAMBOD, M., & AZIZI, FEREYDOUN. (2005). FACTORS INFLUENCING 2-H POSTCHALLENGE PLASMA GLUCOSE AND ISOLATED POSTCHALLENGE HYPERGLYCEMIA; TEHRAN LIPID AND GLUCOSE STUDY (TLGS). IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(SUPPLEMENT 4), 405-414. SID. https://sid.ir/paper/27804/en

Vancouver: Copy

HOSSEINPANAH F., GHAFARI HAMED REZA, RAMBOD M., AZIZI FEREYDOUN. FACTORS INFLUENCING 2-H POSTCHALLENGE PLASMA GLUCOSE AND ISOLATED POSTCHALLENGE HYPERGLYCEMIA; TEHRAN LIPID AND GLUCOSE STUDY (TLGS). IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(SUPPLEMENT 4):405-414. Available from: https://sid.ir/paper/27804/en

IEEE: Copy

F. HOSSEINPANAH, HAMED REZA GHAFARI, M. RAMBOD, and FEREYDOUN AZIZI, “FACTORS INFLUENCING 2-H POSTCHALLENGE PLASMA GLUCOSE AND ISOLATED POSTCHALLENGE HYPERGLYCEMIA; TEHRAN LIPID AND GLUCOSE STUDY (TLGS),” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. SUPPLEMENT 4, pp. 405–414, 2005, [Online]. Available: https://sid.ir/paper/27804/en

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