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Title

OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN

Pages

  27-32

Abstract

 Diagnosis of hepatitis B is routinely based on of serological assay of hepatitis B surface antigen (HBsAg). Occult hepatitis B virus (HBV) infection is generally defined as the detection of HBV-DNA in the serum or tissues of subjects who have negative test for HBsAg. Transmission of HBV infection has been documented from HBsAg negative, anti-HBc positive blood and organ donors. The aim of this study was to determine the rate of occult HBV infection among HBsAg negative and anti- HBc positive BLOOD DONORS of Rafsanjan blood transfusion center. Sera from 270 healthy BLOOD DONORS who were negative for both HBsAg and anti-HCV, were tested for anti-HBc antibodies by use of ELISA technique. The samples that were negative for HBsAg but positive for anti-HBc markers also examined for the presence of HBV-DNA by polymerase chain reaction (PCR). Out of 270 HBsAg negative blood samples, 14 samples (5.18%) were positive for anti-HBc antibodies. HBV-DNA was detected in 4/14 (28.57%) of HBsAg negative and anti-HBc positive samples. Moreover, anti-HBs antibody was detected in 2/4 (50%) of HBV-DNA positive samples. These results indicated that HBVDNA found in the majority of HBsAg negative and anti-HBc-positive donors. In addition, the present study recommend the incorporation of routine anti-HBc screening of blood as a surrogate marker of occult HBV infection to prevent some transfusion-transmitted HBV infections.

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    APA: Copy

    JAFARZADEH, A., KAZEMI ARABABADI, M., MIRZAEI, M., & POURAZAR, A.. (2008). OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN. ACTA MEDICA IRANICA, 46(1), 27-32. SID. https://sid.ir/paper/278040/en

    Vancouver: Copy

    JAFARZADEH A., KAZEMI ARABABADI M., MIRZAEI M., POURAZAR A.. OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN. ACTA MEDICA IRANICA[Internet]. 2008;46(1):27-32. Available from: https://sid.ir/paper/278040/en

    IEEE: Copy

    A. JAFARZADEH, M. KAZEMI ARABABADI, M. MIRZAEI, and A. POURAZAR, “OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN,” ACTA MEDICA IRANICA, vol. 46, no. 1, pp. 27–32, 2008, [Online]. Available: https://sid.ir/paper/278040/en

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