POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE DIABETIC PATIENTS

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NIKZAMIR A.; NAKHJAVANI M.; GOLMOHAMMADI T.; DIBAI L.; SAFARI R.

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Journal: ACTA MEDICA IRANICA Year:2008 | Volume:46 | Issue:4 Page(s): 277-282

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Title

POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE DIABETIC PATIENTS

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Keywords

RENIN-ANGIOTENSIN SYSTEM

ANGIOTENSIN CONVERTING ENZYME

TYPE 2 DIABETES MELLITUS

Abstract

It has recently been shown that an insertion (I)/deletion (D) polymorphism exists in the angiotensin-converting enzyme (ACE) gene that can affect the serum ACE level. There are three genotypes: DD, DI, and II, with the ACE level being highest in DD, intermediate in DI, and lowest in II. The DD genotype has been reported as a genetic risk factor for diabetes mellitus. In the present investigation, 170 patients with TYPE 2 DIABETES MELLITUS (T2DM) and 144 control subjects were studied.The ACE I/D polymorphism was determined by polymerase chain reaction (PCR) utilizing specific primers. ACE activity was determined spectrophotometrically. Distributions of ACE gene (I/D) polymorphism and allele frequencies in patients with T2DM were significantly different from those in control (P < 0.001); D allele frequency was 51% in T2DM vs. 48% in controls. The level of ACE activity was significantly higher in the DD genotype (91.1±23.18) than those in ID (60.6±22.8) and in II genotypes (36.8±6.9). There was a significant difference in genotype distribution between the two groups (P < 0.001). New normal ranges of serum ACE level were determined for each genotype.Moreover, we found test sensitivity to be 62.3%. Serum ACE activity was significantly associated with ACE (I/D) gene polymorphism.

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APA: Copy

NIKZAMIR, A., NAKHJAVANI, M., GOLMOHAMMADI, T., DIBAI, L., & SAFARI, R.. (2008). POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE DIABETIC PATIENTS . ACTA MEDICA IRANICA, 46(4), 277-282. SID. https://sid.ir/paper/278130/en

Vancouver: Copy

NIKZAMIR A., NAKHJAVANI M., GOLMOHAMMADI T., DIBAI L., SAFARI R.. POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE DIABETIC PATIENTS . ACTA MEDICA IRANICA[Internet]. 2008;46(4):277-282. Available from: https://sid.ir/paper/278130/en

IEEE: Copy

A. NIKZAMIR, M. NAKHJAVANI, T. GOLMOHAMMADI, L. DIBAI, and R. SAFARI, “POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE DIABETIC PATIENTS ,” ACTA MEDICA IRANICA, vol. 46, no. 4, pp. 277–282, 2008, [Online]. Available: https://sid.ir/paper/278130/en

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