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Information Journal Paper

Title

ANTIMUTAGENICITY AND ANTICANCER EFFECTS OF CITRUS MEDICA FRUIT JUICE

Pages

  373-377

Abstract

 Currently cancer is considered as one of the main factors of mortality globally. Many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. Nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. The purpose of this research is to examine ANTIMUTAGENICITY and ANTICANCER effect of Citrus Medica fruit juice. In present study HUMAN ASTROCYTOMA CANCER CELLS were cultured in DMEM (Gibco), supplemented with 10% fetal calf serum, peniciline-streptomycin, L-glutamine and incubated at 37°C for 2 days. In addition cancer cell line was treated by half-ripe and ripe Citrus Medica fruit juice and cellular vital capacity was determined by MTT. The Citrus Medica fruit juice was subsequenthy evaluated in terms of ANTIMUTAGENICITY and ANTICANCER properties by a standard reverse mutation assay (Ames Test). This was performed with histidine auxotroph strain of Salmonella typhimurium (TA100). Thus, it requires histidine from a foreign supply to ensure its growth. The aforementioned strain gives rise to reverted colonies when expose to carcinogen substance (Sodium Azide). During MTT, human astrocytoma cell line revealed to have a meaningful cell death when compared with controls (P<0.01). In AMES TEST the fruit juice prevented the reverted mutations and the hindrance percent of half-ripe Citrus Medica was 71.7% and ripe Citrus Medica was 34.4% in ANTIMUTAGENICITY test and this value in ANTICANCER test was 83.3% and 50% in half-ripe Citrus Medica and ripe Citrus Medica respectively. This is the first study that has revealed ANTIMUTAGENICITY and ANTICANCER effect of Citrus Medica fruit juice and the effects were higher in half-ripe Citrus Medica in comparison to the ripened on.

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    APA: Copy

    ENTEZARI, M., MAJD, AHMAD, FALAHIAN, F.A., MEHRABIAN, S., ARDESHIRI LAJIMI, A.A.R., & HASHEMI, MEHRDAD. (2009). ANTIMUTAGENICITY AND ANTICANCER EFFECTS OF CITRUS MEDICA FRUIT JUICE. ACTA MEDICA IRANICA, 47(5), 373-377. SID. https://sid.ir/paper/278280/en

    Vancouver: Copy

    ENTEZARI M., MAJD AHMAD, FALAHIAN F.A., MEHRABIAN S., ARDESHIRI LAJIMI A.A.R., HASHEMI MEHRDAD. ANTIMUTAGENICITY AND ANTICANCER EFFECTS OF CITRUS MEDICA FRUIT JUICE. ACTA MEDICA IRANICA[Internet]. 2009;47(5):373-377. Available from: https://sid.ir/paper/278280/en

    IEEE: Copy

    M. ENTEZARI, AHMAD MAJD, F.A. FALAHIAN, S. MEHRABIAN, A.A.R. ARDESHIRI LAJIMI, and MEHRDAD HASHEMI, “ANTIMUTAGENICITY AND ANTICANCER EFFECTS OF CITRUS MEDICA FRUIT JUICE,” ACTA MEDICA IRANICA, vol. 47, no. 5, pp. 373–377, 2009, [Online]. Available: https://sid.ir/paper/278280/en

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