EFFECTS OF CONTINUOUS AND INTERRUPTED FORCES ON GENE TRANSCRIPTION IN PERIODONTAL LIGAMENT CELLS IN VITRO

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HACOPIAN NINETTE; HOSSEINZADEH NIK TAHEREH; GHAHREMANI MOHAMMAD HOSSEIN; RAHIMI HAMID REZA; OSTAD SEYED NASSER

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Journal: ACTA MEDICA IRANICA Year:2011 | Volume:49 | Issue:10 Page(s): 643-649

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Title

EFFECTS OF CONTINUOUS AND INTERRUPTED FORCES ON GENE TRANSCRIPTION IN PERIODONTAL LIGAMENT CELLS IN VITRO

Author(s)

Keywords

GENE EXPRESSION

STRESS

MECHANICAL

PERIODONTAL LIGAMENT

REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION3

Abstract

The biological mechanisms of tooth movement are based on the response of periodontal tissues to MECHANICAL forces. The final result of these responses is remodeling of the extracellular matrix. Tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. The purpose of the present study was to analyze the effects of centrifugal force on the transcription of collagen type-I (Col-I), matrix metalloproteinase-1 (MMP-1), and tissue inhibitor of metalloproteinase- 1 (TIMP-1) genes in human PERIODONTAL LIGAMENT (PDL) fibroblasts. Human fibroblasts obtained from the PDL were cultured and subjected to centrifugal forces (36.3 g/cm2) for 30, 60 and 90 min continuously. This was also carried out interruptedly, three times for 30 min and six times for 15 min. The mRNAs encoding for Col-I, MMP-1, and TIMP-1 were quantified using RT-PCR. The mRNA levels of Col-I and MMP-1 were increased when continuous force was applied for 30 min and 60 min respectively. The interrupted force had almost no effect on Col-I, MMP-1 and TIMP-1 genes. These results indicate that continuous forces may have a greater effect in inducing GENE EXPRESSION during the remodeling process of PDL compared to interrupted forces with short rest periods.

Cites

ACETAMINOPHEN VERSUS LIQUEFIED IBUPROFEN FOR CONTROL OF PAIN DURING SEPARATION IN ORTHODONTIC PATIENTS: A RANDOMIZED TRIPLE BLINDED CLINICAL TRIAL

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APA: Copy

HACOPIAN, NINETTE, HOSSEINZADEH NIK, TAHEREH, GHAHREMANI, MOHAMMAD HOSSEIN, RAHIMI, HAMID REZA, & OSTAD, SEYED NASSER. (2011). EFFECTS OF CONTINUOUS AND INTERRUPTED FORCES ON GENE TRANSCRIPTION IN PERIODONTAL LIGAMENT CELLS IN VITRO. ACTA MEDICA IRANICA, 49(10), 643-649. SID. https://sid.ir/paper/278548/en

Vancouver: Copy

HACOPIAN NINETTE, HOSSEINZADEH NIK TAHEREH, GHAHREMANI MOHAMMAD HOSSEIN, RAHIMI HAMID REZA, OSTAD SEYED NASSER. EFFECTS OF CONTINUOUS AND INTERRUPTED FORCES ON GENE TRANSCRIPTION IN PERIODONTAL LIGAMENT CELLS IN VITRO. ACTA MEDICA IRANICA[Internet]. 2011;49(10):643-649. Available from: https://sid.ir/paper/278548/en

IEEE: Copy

NINETTE HACOPIAN, TAHEREH HOSSEINZADEH NIK, MOHAMMAD HOSSEIN GHAHREMANI, HAMID REZA RAHIMI, and SEYED NASSER OSTAD, “EFFECTS OF CONTINUOUS AND INTERRUPTED FORCES ON GENE TRANSCRIPTION IN PERIODONTAL LIGAMENT CELLS IN VITRO,” ACTA MEDICA IRANICA, vol. 49, no. 10, pp. 643–649, 2011, [Online]. Available: https://sid.ir/paper/278548/en

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