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Information Journal Paper

Title

HOW CAN 5-HT3 RECEPTOR ANTAGONISTS EXERT ANALGESIC PROPERTIES? (LETTER TO EDITOR)

Pages

  0-0

Keywords

Not Registered.

Abstract

 5-HT3 receptors occur on various components of the pain modulation system. Expressed on peripheral nerve endings and autonomic afferents as well as in the monoaminergic descending inhibitory system and certain brain regions, 5-HT3 receptors play an indispensable role in spinal pain transmission and endogenous pain suppression. Yet, their role in this context has not been defined lucidly, and studies have yielded fairly controversial results. The stimulation of spinal 5-HT3 receptors in the dorsal horn has an antinociceptive effect in acute pain models, probably via release of GABA and consequent activation of the descending inhibitory system. This antinociceptive effect is reasonably abolished by the administration of 5-HT3 receptor antagonists. In chronic pain, however, different situation reigns.

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    • Cite

    APA: Copy

    NOROUZI, ABBAS, FAKHFOURI, GOHAR, & RAHIMIAN, REZA. (2012). HOW CAN 5-HT3 RECEPTOR ANTAGONISTS EXERT ANALGESIC PROPERTIES? (LETTER TO EDITOR). ACTA MEDICA IRANICA, 50(4), 0-0. SID. https://sid.ir/paper/278584/en

    Vancouver: Copy

    NOROUZI ABBAS, FAKHFOURI GOHAR, RAHIMIAN REZA. HOW CAN 5-HT3 RECEPTOR ANTAGONISTS EXERT ANALGESIC PROPERTIES? (LETTER TO EDITOR). ACTA MEDICA IRANICA[Internet]. 2012;50(4):0-0. Available from: https://sid.ir/paper/278584/en

    IEEE: Copy

    ABBAS NOROUZI, GOHAR FAKHFOURI, and REZA RAHIMIAN, “HOW CAN 5-HT3 RECEPTOR ANTAGONISTS EXERT ANALGESIC PROPERTIES? (LETTER TO EDITOR),” ACTA MEDICA IRANICA, vol. 50, no. 4, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/278584/en

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