ADMINISTRATION OF HIGHER DOSES OF AMIKACIN IN EARLY STAGES OF SEPSIS IN CRITICALLY ILL PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAJMEDDIN FARHAD; AHMADI AREZOO; MAHMOUDI LALEH; KHALILI HOSSEIN; AHMADVAND ALIREZA; NAJAFI ATABAK; MOJTAHEDZADEH MOJTABA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ACTA MEDICA IRANICA Year:2014 | Volume:52 | Issue:9 Page(s): 703-709

Download Full-Text

View:

493

Download:

180

Cites:

Information Journal Paper

Title

ADMINISTRATION OF HIGHER DOSES OF AMIKACIN IN EARLY STAGES OF SEPSIS IN CRITICALLY ILL PATIENTS

Author(s)

Keywords

AMIKACIN

HIGH-DOSE EXTENDED-INTERVAL DOSAGE

MODERATE-DOSE NON-LIBERAL-INTERVAL DOSAGE

HIGH-DOSE NON-LIBERAL-INTERVAL DOSAGE

NEPHROTOXICITY

SERUM NGAL

TUBULAR INJURY BIOMARKER

Abstract

High-dose extended-interval dosage (HDED) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. Although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %T>MIC less than 60% of the dosing interval following extended interval dosing. Moreover, limited information is available about safety of more frequent administration of high dose aminoglycosides. Authors studied NEPHROTOXICITY following seven days’ exposure to more frequent administration of higher doses of AMIKACIN comparing with HDED regimen. In addition to Serum Creatinine (SrCr) and estimated glomerular filtration rate (eGFR), NEPHROTOXICITY was studied with Neutrophil gelatinase-associated lipocalin (NGAL), a direct marker of tubular injury. A total of 40 patients with sepsis were quasi-randomized in two groups. Seven days’ course of treatment with a moderate dose of AMIKACIN (12.5 mg/Kg) was administered every 12 hours, known as the MODERATE-DOSE NON-LIBERAL-INTERVAL DOSAGE (MDNLD) regimen compared with the HIGH-DOSE EXTENDED-INTERVAL DOSAGE (HDED) regimen (25mg/Kg every 24 hours). The pharmacokinetic/pharmacodynamic (PK/PD) goal of the MDNLD regimen was the Cmax>40 and the %T>MIC more than 60% during the PK/PD goal for the HDED regimen was the Cmax>60. The eGFR change from the baseline was the primary outcome of the study with a minimum clinical significance of 20ml/min (estimated SD of 20, Power>90%, P<0.05). No difference was observed between groups for the values of eGFR change and the SrCr percent change from the baseline (P=0.359 and P=0.114, respectively). Frequency of acute kidney injury also did not differ between groups (P=0.342). SERUM NGAL level values’ change from the baseline was more in the HDED regimen in comparison with the MDNLD regimen at third day and fifth day of the treatment (P=0.001 and P=0.002, respectively). This indicates a safer pattern of moderate doses with more frequent administration of AMIKACIN at the tubular injury level. Higher doses of AMIKACIN could be safely administered to achieve PK/PD goal of Cmax>40 and %T>MIC more than 60% of the dosing interval. This dosing regimen would be considered as an alternative to minimize the resistance development associated with the extended-interval dosing in septic patients with multi-drug resistant gram-negative organisms.

Cites

No record.

References

Cite

APA: Copy

NAJMEDDIN, FARHAD, AHMADI, AREZOO, MAHMOUDI, LALEH, KHALILI, HOSSEIN, AHMADVAND, ALIREZA, NAJAFI, ATABAK, & MOJTAHEDZADEH, MOJTABA. (2014). ADMINISTRATION OF HIGHER DOSES OF AMIKACIN IN EARLY STAGES OF SEPSIS IN CRITICALLY ILL PATIENTS. ACTA MEDICA IRANICA, 52(9), 703-709. SID. https://sid.ir/paper/278643/en

Vancouver: Copy

NAJMEDDIN FARHAD, AHMADI AREZOO, MAHMOUDI LALEH, KHALILI HOSSEIN, AHMADVAND ALIREZA, NAJAFI ATABAK, MOJTAHEDZADEH MOJTABA. ADMINISTRATION OF HIGHER DOSES OF AMIKACIN IN EARLY STAGES OF SEPSIS IN CRITICALLY ILL PATIENTS. ACTA MEDICA IRANICA[Internet]. 2014;52(9):703-709. Available from: https://sid.ir/paper/278643/en

IEEE: Copy

FARHAD NAJMEDDIN, AREZOO AHMADI, LALEH MAHMOUDI, HOSSEIN KHALILI, ALIREZA AHMADVAND, ATABAK NAJAFI, and MOJTABA MOJTAHEDZADEH, “ADMINISTRATION OF HIGHER DOSES OF AMIKACIN IN EARLY STAGES OF SEPSIS IN CRITICALLY ILL PATIENTS,” ACTA MEDICA IRANICA, vol. 52, no. 9, pp. 703–709, 2014, [Online]. Available: https://sid.ir/paper/278643/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops