THE EFFECT OF HMG-COA REDUCTASE INHIBITOR (LOVASTATIN) ON BONE MINERAL DENSITY (BMD) IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAFAEI H.; AMINI MASOUD; JANGHORBANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2005 | Volume:7 | Issue:2 (SN 26) Page(s): 135-142

Download Full-Text

Persian Verion

View:

813

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF HMG-COA REDUCTASE INHIBITOR (LOVASTATIN) ON BONE MINERAL DENSITY (BMD) IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES

Author(s)

SAFAEI H. | AMINI MASOUD | JANGHORBANI M. | Issue Writer Certificate

Keywords

TYPE 2 DIABETESQ2

OSTEOPOROSISQ4

BONE MINERAL DENSITYQ3

LOVASTATINQ4

Abstract

Introduction: Decreased rates of bone fracture have been reported in hypercholesterolemic patients treated with statin compounds. Considering the higher prevalence of bone fractures in diabetic patients compared to non-diabetics, this study was performed to determine the effect of LOVASTATIN on the BONE MINERAL DENSITY (BMD) of postmenopausal women with TYPE 2 DIABETES. Materials & Methods: In this clinical trial study, 60 postmenopausal women with TYPE 2 DIABETES were divided into 2 groups (with and without hypercholesterolemia) matched for age, diabetes duration, BMI and duration of menopause. Hypercholesterolemic subjects were treated with LOVASTATIN for 18 months. Using DXA, bone densitometries was performed in all patients before and at the end of the study and the results were compared. Results: Total hip and lumbar spine BMD significantly increased in the treated group (p<0.01). In control subjects BMD decreased in total hip and increased in lumbar spine, but not significantly. Percentage changes of BMD in the femoral neck, wards triangle, trochanter, total hip and lumbar spine were 3.5% ,15.7% , 1.7%,3.29% and 3.2% respectively in the treated group as compared to -2.54% , 3% ,-2.2% , -2.2% and 1.1% in control subjects, respectively. Conclusion: According to our findings, LOVASTATIN can increase the BMD in postmenopausal women with TYPE 2 DIABETES. It seems that these agents may slow the process of OSTEOPOROSIS or stop its progression, especially in hypercholesterolemic patients.

Cites

No record.

References

No record.

Cite

APA: Copy

SAFAEI, H., AMINI, MASOUD, & JANGHORBANI, M.. (2005). THE EFFECT OF HMG-COA REDUCTASE INHIBITOR (LOVASTATIN) ON BONE MINERAL DENSITY (BMD) IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(2 (SN 26)), 135-142. SID. https://sid.ir/paper/27866/en

Vancouver: Copy

SAFAEI H., AMINI MASOUD, JANGHORBANI M.. THE EFFECT OF HMG-COA REDUCTASE INHIBITOR (LOVASTATIN) ON BONE MINERAL DENSITY (BMD) IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(2 (SN 26)):135-142. Available from: https://sid.ir/paper/27866/en

IEEE: Copy

H. SAFAEI, MASOUD AMINI, and M. JANGHORBANI, “THE EFFECT OF HMG-COA REDUCTASE INHIBITOR (LOVASTATIN) ON BONE MINERAL DENSITY (BMD) IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. 2 (SN 26), pp. 135–142, 2005, [Online]. Available: https://sid.ir/paper/27866/en

Related Journal Papers