A STUDY ON THE FRAGILITY OF RED BLOOD CELLS IN HYPOTHYROID RATS

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ZAHEDI S.; NABAVIZADEH RAFSANJANI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2002 | Volume:4 | Issue:2 (SN 14) Page(s): 117-120

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Information Journal Paper

Title

A STUDY ON THE FRAGILITY OF RED BLOOD CELLS IN HYPOTHYROID RATS

Author(s)

ZAHEDI S. | NABAVIZADEH RAFSANJANI F. | Issue Writer Certificate

Keywords

ANEMIAQ3

HYPOTHYROIDISMQ4

RATSQ2

FRAGILITYQ4

RED BLOOD CELLSQ4

Abstract

Introduction: HYPOTHYROIDISM causes many hematologic abnormalities including ANEMIA. ANEMIA can be due to iron deficiency, impaired hemoglobin synthesis, poor diet, structural abnormalities of the RED BLOOD CELLS (RBC) and reduced half-life of RBC. In this study RBC FRAGILITY in hypothyroid RATS were compared to that of control animals Materials and method: HYPOTHYROIDISM was induced by methimazole (500 mg/L of drinking water for 20 days) in the RATS (body weight, 246±5gr). Blood samples were collected through carotid vein on EDTA for osmotic FRAGILITY test. RBC FRAGILITY of RBC was tested by a routine method in which the cells were placed in different concentrations of NaCl (0.09 gr/L) and hemolysis was determined by colorimetric method. The hemolysis precentage of the samples in each solution was calculated on the basis of the 100% hemolysis in distilled water. Results: RBCs from hypothyroid animals had significantly (p<0.05) higher hemolysis in NaCl concentrations of 2.5, 3, 4, 4.5, 5, 5.5, 6 and 7 gr/L as compared to control animals. Conclusion: Results of this study prove that ANEMIA in hypothyroid RATS could also be due to increased FRAGILITY of RBC.

Cites

HEMATOLOGY AND OSMOTIC FRAGILITY OF RED BLOOD CELLS IN HYPERTHYROID RATS

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APA: Copy

ZAHEDI, S., & NABAVIZADEH RAFSANJANI, F.. (2002). A STUDY ON THE FRAGILITY OF RED BLOOD CELLS IN HYPOTHYROID RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 4(2 (SN 14)), 117-120. SID. https://sid.ir/paper/27884/en

Vancouver: Copy

ZAHEDI S., NABAVIZADEH RAFSANJANI F.. A STUDY ON THE FRAGILITY OF RED BLOOD CELLS IN HYPOTHYROID RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2002;4(2 (SN 14)):117-120. Available from: https://sid.ir/paper/27884/en

IEEE: Copy

S. ZAHEDI, and F. NABAVIZADEH RAFSANJANI, “A STUDY ON THE FRAGILITY OF RED BLOOD CELLS IN HYPOTHYROID RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 4, no. 2 (SN 14), pp. 117–120, 2002, [Online]. Available: https://sid.ir/paper/27884/en

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