ENHANCEMENT OF CISPLATIN NEPHROTOXICITY BY MORPHINE AND ITS ATTENUATION BY THE OPIOID ANTAGONIST NALTREXONE

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AMINIAN ATEFEH; JAVADI SHIVA; RAHIMIAN REZA; DEHPOUR AHMAD REZA; ASADI AMOLI FAHIMEH; MOGHADDAS PAYMAN; EJTEMAEI MEHR SHAHRAM

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Journal: ACTA MEDICA IRANICA Year:2016 | Volume:54 | Issue:7 Page(s): 422-429

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Title

ENHANCEMENT OF CISPLATIN NEPHROTOXICITY BY MORPHINE AND ITS ATTENUATION BY THE OPIOID ANTAGONIST NALTREXONE

Author(s)

Keywords

CISPLATIN

MORPHINE

NALTREXONE

ANTIOXIDANT

NEPHROTOXICITY

IMMUNOMODULATORY

Abstract

Nephrotoxicity is a major side effect of CISPLATIN, a widely used chemotherapy agent. MORPHINE and other opioids are also used extensively in different types of cancer for the clinical management of pain associated with local or metastatic neoplastic lesions. In addition to its analgesic effects, MORPHINE has also been reported to possess potential IMMUNOMODULATORY and ANTIOXIDANT properties. Herein, we investigated the effects of MORPHINE in a rat model of CISPLATIN-induced NEPHROTOXICITY. Following administration of a single dose of CISPLATIN (5 mg/kg), animals received intraperitoneal injections of MORPHINE (5 mg/kg/day) and/or NALTREXONE (20 mg/kg/day), an opioid antagonist, for 5 days. CISPLATIN-induced NEPHROTOXICITY was detected by a significant increase in plasma urea and creatinine levels in addition to alterations in kidney tissue morphology. Levels of TNF-a and IL-1b were significantly increased in the renal tissue in CISPLATIN group.Moreover, glutathione (GSH) concentration and superoxide dismutase activity were significantly reduced in renal tissue in CISPLATIN group compared with control animals. Treatment with MORPHINE aggravated the deleterious effects of CISPLATIN at clinical, biochemical and histopathological levels, whereas NALTREXONE diminished the detrimental effects of MORPHINE in animals receiving MORPHINE and CISPLATIN. MORPHINE or NALTREXONE alone had no effect on the mentioned parameters. Ourfindings indicate that concomitant treatment with MORPHINE might intensify CISPLATIN-induced renal damage in rats. These findings suggest that MORPHINE and other opioids should be administered cautiously in patients receiving CISPLATIN chemotherapy.

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APA: Copy

AMINIAN, ATEFEH, JAVADI, SHIVA, RAHIMIAN, REZA, DEHPOUR, AHMAD REZA, ASADI AMOLI, FAHIMEH, MOGHADDAS, PAYMAN, & EJTEMAEI MEHR, SHAHRAM. (2016). ENHANCEMENT OF CISPLATIN NEPHROTOXICITY BY MORPHINE AND ITS ATTENUATION BY THE OPIOID ANTAGONIST NALTREXONE. ACTA MEDICA IRANICA, 54(7), 422-429. SID. https://sid.ir/paper/278860/en

Vancouver: Copy

AMINIAN ATEFEH, JAVADI SHIVA, RAHIMIAN REZA, DEHPOUR AHMAD REZA, ASADI AMOLI FAHIMEH, MOGHADDAS PAYMAN, EJTEMAEI MEHR SHAHRAM. ENHANCEMENT OF CISPLATIN NEPHROTOXICITY BY MORPHINE AND ITS ATTENUATION BY THE OPIOID ANTAGONIST NALTREXONE. ACTA MEDICA IRANICA[Internet]. 2016;54(7):422-429. Available from: https://sid.ir/paper/278860/en

IEEE: Copy

ATEFEH AMINIAN, SHIVA JAVADI, REZA RAHIMIAN, AHMAD REZA DEHPOUR, FAHIMEH ASADI AMOLI, PAYMAN MOGHADDAS, and SHAHRAM EJTEMAEI MEHR, “ENHANCEMENT OF CISPLATIN NEPHROTOXICITY BY MORPHINE AND ITS ATTENUATION BY THE OPIOID ANTAGONIST NALTREXONE,” ACTA MEDICA IRANICA, vol. 54, no. 7, pp. 422–429, 2016, [Online]. Available: https://sid.ir/paper/278860/en

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