PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE

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NIKOUI VAHID; JAVADI PAYDAR MEHRAK; SALEHI MAHTAB; BEHESTANI SELDA; DEHPOUR AHMAD REZA

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Journal: ACTA MEDICA IRANICA Year:2016 | Volume:54 | Issue:4 Page(s): 226-232

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Title

PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE

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Keywords

LITHIUM

SUMATRIPTAN

5-HT1B/1D

SPATIAL RECOGNITION MEMORY

MICE

Abstract

LITHIUM is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that LITHIUM can antagonize the 5-HT1B/1D serotonin receptors. SUMATRIPTAN is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of LITHIUM on SUMATRIPTAN-induced memory impairment have been determined in a two-trial recognition Y-maze and passive avoidance tests.Male MICE weighing 25-30 g were divided into several groups randomly. In Y-maze test, effects of LITHIUM (1, 5, 10, 20, 40, 80 mg/kg) and SUMATRIPTAN (1, 5, 10 mg/kg) were assessed on memory acquisition, then LITHIUM (0.1, 1, 10 mg/kg) and SUMATRIPTAN (1, 10 mg/kg) were studied in passive avoidance test. Effects of LITHIUM (1mg/kg) on SUMATRIPTAN (10 mg/kg) -induced memory impairment were studied in both of tests. The present study demonstrated that SUMATRIPTAN impaired memory in Y-maze and passive avoidance tests (P<0.05, P<0.01, respectively). LITHIUM did not show any significant effect on memory function compared to salinetreated control group in both tests (P>0.05), but significantly reversed SUMATRIPTAN-induced memory impairment in Y-maze and passive avoidance tests (P<0.001, P<0.05, respectively). It is concluded that LITHIUM reverses the SUMATRIPTAN-induced memory impairment probably through 5-HT1B/1D receptors antagonism.

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APA: Copy

NIKOUI, VAHID, JAVADI PAYDAR, MEHRAK, SALEHI, MAHTAB, BEHESTANI, SELDA, & DEHPOUR, AHMAD REZA. (2016). PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE. ACTA MEDICA IRANICA, 54(4), 226-232. SID. https://sid.ir/paper/278878/en

Vancouver: Copy

NIKOUI VAHID, JAVADI PAYDAR MEHRAK, SALEHI MAHTAB, BEHESTANI SELDA, DEHPOUR AHMAD REZA. PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE. ACTA MEDICA IRANICA[Internet]. 2016;54(4):226-232. Available from: https://sid.ir/paper/278878/en

IEEE: Copy

VAHID NIKOUI, MEHRAK JAVADI PAYDAR, MAHTAB SALEHI, SELDA BEHESTANI, and AHMAD REZA DEHPOUR, “PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE,” ACTA MEDICA IRANICA, vol. 54, no. 4, pp. 226–232, 2016, [Online]. Available: https://sid.ir/paper/278878/en

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