ATTENUATED LEAD INDUCED APOPTOSIS IN RAT HEPATOCYTES IN THE PRESENCE OF LYCOPERSICON ESCULENTUM

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AHMADI ASHTIANI HAMIDREZA; KHAKI ARASH; EJTEMAEI MEHR SHAHRAM; ANJARANI SOGHRA; DADGARNEJAD MANOCHEHR; ALEBOUYEH MAHMOUD; RASTEGAR HOSSEIN

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Journal: ACTA MEDICA IRANICA Year:2016 | Volume:54 | Issue:4 Page(s): 240-244

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Title

ATTENUATED LEAD INDUCED APOPTOSIS IN RAT HEPATOCYTES IN THE PRESENCE OF LYCOPERSICON ESCULENTUM

Author(s)

Keywords

LEAD

APOPTOSIS

HEPATOCYTES

LYCOPERSICON

Abstract

LEAD (Pb), has, for decades, being known for its adverse effects on various body organs and systems. In the present study, the damage of Pb on the Liver tissue APOPTOSIS was investigated, and LYCOPERSICON esculentum as an antioxidants source was administered orally to prevent the adverse effects of Pb. Eighteen Wistar rats, randomized into three groups (n=6), were used for this study. Animals in Group A served as the control and were drinking distilled water. Animals in Groups B and C were drinking 1%LEAD acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml/day of LYCOPERSICON esculentum. Treatments were for three months. The obtained results showed that LEAD acetate caused significant reductions in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma and tissue malondialdehyde concentration but LYCOPERSICON esculentum have an inhibitory effect on LA liver adverse effect. So, it can be concluded that LYCOPERSICON esculentum have a significant protective effect on liver LEAD acetate adverse effects as well as, LEAD acetate -induced oxidative stress.

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APA: Copy

AHMADI ASHTIANI, HAMIDREZA, KHAKI, ARASH, EJTEMAEI MEHR, SHAHRAM, ANJARANI, SOGHRA, DADGARNEJAD, MANOCHEHR, ALEBOUYEH, MAHMOUD, & RASTEGAR, HOSSEIN. (2016). ATTENUATED LEAD INDUCED APOPTOSIS IN RAT HEPATOCYTES IN THE PRESENCE OF LYCOPERSICON ESCULENTUM. ACTA MEDICA IRANICA, 54(4), 240-244. SID. https://sid.ir/paper/278879/en

Vancouver: Copy

AHMADI ASHTIANI HAMIDREZA, KHAKI ARASH, EJTEMAEI MEHR SHAHRAM, ANJARANI SOGHRA, DADGARNEJAD MANOCHEHR, ALEBOUYEH MAHMOUD, RASTEGAR HOSSEIN. ATTENUATED LEAD INDUCED APOPTOSIS IN RAT HEPATOCYTES IN THE PRESENCE OF LYCOPERSICON ESCULENTUM. ACTA MEDICA IRANICA[Internet]. 2016;54(4):240-244. Available from: https://sid.ir/paper/278879/en

IEEE: Copy

HAMIDREZA AHMADI ASHTIANI, ARASH KHAKI, SHAHRAM EJTEMAEI MEHR, SOGHRA ANJARANI, MANOCHEHR DADGARNEJAD, MAHMOUD ALEBOUYEH, and HOSSEIN RASTEGAR, “ATTENUATED LEAD INDUCED APOPTOSIS IN RAT HEPATOCYTES IN THE PRESENCE OF LYCOPERSICON ESCULENTUM,” ACTA MEDICA IRANICA, vol. 54, no. 4, pp. 240–244, 2016, [Online]. Available: https://sid.ir/paper/278879/en

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