Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer

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Sadeghipour Narges; Lotfiyani Farnaz; RAOOFIAN REZA; NOORI DALOII MOHAMMAD REZA; AZIMI CYRUS; HEIDARI MANSOUR

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Journal Paper

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Journal: ACTA MEDICA IRANICA Year:2018 | Volume:56 | Issue:10 Page(s): 653-659

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Title

Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer

Author(s)

Keywords

Colorectal cancer

TGIFLX

OCT1

Real time RT-PCR

Abstract

The OCT1 and TGIFLX transcription factors are members of homeodomains whose expressions have been implicated in normal and abnormal development. However, the expression of TGIFLX and OCT1 in Colorectal cancer is unknown. This study aimed to detect the expression of OCT1 and TGIFLX in clinical samples of Colorectal cancer. Twenty-six pairs of Colorectal cancer tissue and adjacent non-tumoral tissue were obtained at the time of surgery from patients with Colorectal cancer. The expression of TGIFLX and OCT1 was detected by real time reverse transcriptase polymerase chain reaction (RT-PCR). OCT1 was down-regulated in colorectal carcinoma samples in both males (58. 33%) and females (57. 14%). By contrast, TGIFLX was mainly (41. 63%) expressed in colorectal tumors of males' samples but not in para-neoplastic normal tissues. OCT1 expression was not significantly associated with the gender and site of primary tumor (P>0. 05), but the expression of TGIFLX was associated with male patients (P<0. 05). In conclusion, dysregulation of OCT1 and TGIFLX genes might be novel prognostic biomarkers for patients with Colorectal cancer.

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APA: Copy

Sadeghipour, Narges, Lotfiyani, Farnaz, RAOOFIAN, REZA, NOORI DALOII, MOHAMMAD REZA, AZIMI, CYRUS, & HEIDARI, MANSOUR. (2018). Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer. ACTA MEDICA IRANICA, 56(10), 653-659. SID. https://sid.ir/paper/279035/en

Vancouver: Copy

Sadeghipour Narges, Lotfiyani Farnaz, RAOOFIAN REZA, NOORI DALOII MOHAMMAD REZA, AZIMI CYRUS, HEIDARI MANSOUR. Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer. ACTA MEDICA IRANICA[Internet]. 2018;56(10):653-659. Available from: https://sid.ir/paper/279035/en

IEEE: Copy

Narges Sadeghipour, Farnaz Lotfiyani, REZA RAOOFIAN, MOHAMMAD REZA NOORI DALOII, CYRUS AZIMI, and MANSOUR HEIDARI, “Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer,” ACTA MEDICA IRANICA, vol. 56, no. 10, pp. 653–659, 2018, [Online]. Available: https://sid.ir/paper/279035/en

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