EFFECT OF A2-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESFANDI F.; PAJHAN N.; MOHAMMAD TAGHVAEI N.; KOMEYLI MOVAHED T.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2004 | Volume:5 | Issue:4 (SN 20) Page(s): 227-236

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

922

Download:

Cites:

Information Journal Paper

Title

EFFECT OF A2-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS

Author(s)

ESFANDI F. | PAJHAN N. | MOHAMMAD TAGHVAEI N. | KOMEYLI MOVAHED T. | Issue Writer Certificate

Keywords

OBESITYQ2

A2- ADRENERGIC RECEPTORQ4

YOHIMBINEQ3

CAMPQ4

LEPTINQ3

TNF-AQ2

FFAQ4

Abstract

Introduction: OBESITY is a major risk factor for type 2 diabetes, hypertension, hyperlipidemia, cardiovascular disease and certain types of cancer. Furthermore, OBESITY is associated with insulin resistance and hyperinsulinaemia. Hormones and cytokines such as LEPTIN and TNF-a. are produced by adipose tissue and have a key role in insulin resistance of OBESITY. The purpose of this study was to examine the effects of peripheral administration of YOHIMBINE on some of adipose factors. Materials and Methods: Experiments were carried out on two groups of male rats: lean control group (fed standard purina rodent chow) and obese group (fed cafeteria diet). A blood sample was taken from each rat, after exposure to diet for 18 weeks. The obese group were randomly divided into two groups. Group I was injected with 4mg/kg YOHIMBINE and group II received the equal volume of saline. Blood samples were taken 30, 60, and 120 min after drug or saline injection. Results: Insulin level was significantly increased 30 and 60 minutes after injection (P<0.05). TNF-a and LEPTIN levels were decreased (P<0.05) while FFA level was increased in response to YOHIMBINE, 30 minutes after injection. Glucose level was increased but it was lower than control group during 120 minutes. Conclusion: It has been shown previously that CAMP is the main regulatory factor of LEPTIN, TNF-a and FFA in adipocytes. In comparison to the obtained results in the control group, we conclude that probably sensitivity of a2- adrenergic receptors and a2/b-AR proportion are increased in OBESITY.

Cites

No record.

References

No record.

Cite

APA: Copy

ESFANDI, F., PAJHAN, N., MOHAMMAD TAGHVAEI, N., & KOMEYLI MOVAHED, T.. (2004). EFFECT OF A₂-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 5(4 (SN 20)), 227-236. SID. https://sid.ir/paper/27906/en

Vancouver: Copy

ESFANDI F., PAJHAN N., MOHAMMAD TAGHVAEI N., KOMEYLI MOVAHED T.. EFFECT OF A₂-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2004;5(4 (SN 20)):227-236. Available from: https://sid.ir/paper/27906/en

IEEE: Copy

F. ESFANDI, N. PAJHAN, N. MOHAMMAD TAGHVAEI, and T. KOMEYLI MOVAHED, “EFFECT OF A₂-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 5, no. 4 (SN 20), pp. 227–236, 2004, [Online]. Available: https://sid.ir/paper/27906/en

Related Journal Papers