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Information Journal Paper

Title

Preptin and Myostatin Independently Increase in Pre-Diabetics and Patients of Type 2 Diabetes Mellitus

Pages

  160-166

Abstract

 The relation between serum Preptin, Myostatin, Insulin, and also homeostatic model assessmentInsulin resistance were examined in pre-diabetes persons and newly diagnosed patients with overt Type 2 diabetes mellitus. A total of 84 subjects were included in the study and assigned into three groups: normoglycemic participants (group 1=27), pre-diabetes (group 2=30), and T2DM (group 3=29). Serum Insulin, Preptin, and Myostatin levels were measured with immunoradiometric assay (IRMA), enzyme-linked immunosorbent assay (ELISA), and chemiluminescent immunoassay (CLIA), respectively. Patients with T2DM had higher levels of Preptin compared to normoglycemic (461. 25± 53. 90 vs. 407. 54± 54. 78, P<0. 001). Furthermore, these patients had elevated levels of Myostatin compared with controls (2710. 60± 559. 09 vs. 2246. 37± 416. 40, P<0. 001). Preptin and Myostatin both positively correlated with serum Insulin (r=0. 369, P=0. 01, and r=0. 309, P=0. 04, respectively). However, no significant association was found between serum Preptin and Myostatin levels. Stepwise multiple regression analysis showed that Insulin was affected more by Preptin, with only a trivial contribution from Myostatin. Serum Preptin and Myostatin levels increase in prediabetic subjects and even further in type 2 diabetic patients. The correlation between Preptin and Insulin evolves when pre-diabetes or overt Type 2 diabetes develops. Moreover, serum Myostatin increases in association with Insulin and not HOMA-IR in diabetic conditions.

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    • Cite

    APA: Copy

    Nazari Soltan Ahmad, Saeed, Nourollahi, Sajjad, NAKHJAVANI, MANOUCHEHR, Khojastehfard, Mehran, MOSTAFAZADEH, MOSTAFA, HAJIPOUR, HAMED, & Sanajou, Davoud. (2019). Preptin and Myostatin Independently Increase in Pre-Diabetics and Patients of Type 2 Diabetes Mellitus. ACTA MEDICA IRANICA, 57(3), 160-166. SID. https://sid.ir/paper/279071/en

    Vancouver: Copy

    Nazari Soltan Ahmad Saeed, Nourollahi Sajjad, NAKHJAVANI MANOUCHEHR, Khojastehfard Mehran, MOSTAFAZADEH MOSTAFA, HAJIPOUR HAMED, Sanajou Davoud. Preptin and Myostatin Independently Increase in Pre-Diabetics and Patients of Type 2 Diabetes Mellitus. ACTA MEDICA IRANICA[Internet]. 2019;57(3):160-166. Available from: https://sid.ir/paper/279071/en

    IEEE: Copy

    Saeed Nazari Soltan Ahmad, Sajjad Nourollahi, MANOUCHEHR NAKHJAVANI, Mehran Khojastehfard, MOSTAFA MOSTAFAZADEH, HAMED HAJIPOUR, and Davoud Sanajou, “Preptin and Myostatin Independently Increase in Pre-Diabetics and Patients of Type 2 Diabetes Mellitus,” ACTA MEDICA IRANICA, vol. 57, no. 3, pp. 160–166, 2019, [Online]. Available: https://sid.ir/paper/279071/en

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