PROTECTIVE EFFECT OF VITAMIN E ON DIABETES INDUCED APOPTOSIS AND OXIDATIVE STRESS IN RAT HEART TISSUE

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SHIRPOUR A.R.; SALAMI S.; KHADEM ANSARI M.H.; GHADERI PAKDEL F.; KHADEM VATAN K.; SAADATIAN R.; KARIMIPOUR M.

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Title

PROTECTIVE EFFECT OF VITAMIN E ON DIABETES INDUCED APOPTOSIS AND OXIDATIVE STRESS IN RAT HEART TISSUE

Author(s)

Keywords

DIABETESQ3

VITAMIN EQ2

WISTAR RATQ2

CARDIOMYOCYTEQ2

APOPTOSISQ2

OXIDATIVE STRESSQ2

Abstract

Introduction: The purpose of this study was to determine and to assess the protective effect of VITAMIN E on CARDIOMYOCYTE APOPTOSIS and OXIDATIVE STRESS status in the heart under hyperglycemic conditions, in vivo. Materias and Methods: Wistar male rats (n=16) at 6 months of age were made hyperglycemic by STZ. Same age, normal WISTAR RATs (n=8) were used for comparison (controls). Diabetic rats were divided into two groups, the nontreated and those treated with VITAMIN E (300mg/kg/daily). Results: Diabetic rats exhibited severe APOPTOSIS in CARDIOMYOCYTEs. Also significant increases in lipid peroxidation as measured by 8- isoprostan, protein oxidation as measured by protein carbonyl content and superoxide dismutase were observed after 6 weeks. Catalase activity was shown to increase in controls compared to nontreated rats. A distinct elevation in the HbA1C, QT interval and a decline in the activity of catalase were also observed. VITAMIN E treated rats shown significant decline in APOPTOSIS, lipid peroxidation, protein carbonyl and QT interval compared to nontreated rats. Conclusion: VITAMIN E decreased the incidence of APOPTOSIS in CARDIOMYOCYTEs, lipid peroxidation and improve antioxidant enzyme in the diabetic hearts of rats. Further research to confirm the findings is recommended.

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APA: Copy

SHIRPOUR, A.R., SALAMI, S., KHADEM ANSARI, M.H., GHADERI PAKDEL, F., KHADEM VATAN, K., SAADATIAN, R., & KARIMIPOUR, M.. (2008). PROTECTIVE EFFECT OF VITAMIN E ON DIABETES INDUCED APOPTOSIS AND OXIDATIVE STRESS IN RAT HEART TISSUE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(1 (SN 37)), 67-74. SID. https://sid.ir/paper/27925/en

Vancouver: Copy

SHIRPOUR A.R., SALAMI S., KHADEM ANSARI M.H., GHADERI PAKDEL F., KHADEM VATAN K., SAADATIAN R., KARIMIPOUR M.. PROTECTIVE EFFECT OF VITAMIN E ON DIABETES INDUCED APOPTOSIS AND OXIDATIVE STRESS IN RAT HEART TISSUE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;10(1 (SN 37)):67-74. Available from: https://sid.ir/paper/27925/en

IEEE: Copy

A.R. SHIRPOUR, S. SALAMI, M.H. KHADEM ANSARI, F. GHADERI PAKDEL, K. KHADEM VATAN, R. SAADATIAN, and M. KARIMIPOUR, “PROTECTIVE EFFECT OF VITAMIN E ON DIABETES INDUCED APOPTOSIS AND OXIDATIVE STRESS IN RAT HEART TISSUE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 1 (SN 37), pp. 67–74, 2008, [Online]. Available: https://sid.ir/paper/27925/en

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