INFLUENCE OF RESISTANCE TRAINING ON IL-15 MRNA EXPRESSION AND THE PROTEIN CONTENT IN SLOW AND FAST TWITCH MUSCLES OF DIABETIC RATS

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MOLANOURI SHAMSI M.; MOHAMMAD HASSAN Z.; MAHDAVI M.; GHARAKHANLOU R.; BAGHERSAD L.; AZADMANESH K.; EDALAT R.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2012 | Volume:14 | Issue:2 (SN 62) Page(s): 185-192

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Title

INFLUENCE OF RESISTANCE TRAINING ON IL-15 MRNA EXPRESSION AND THE PROTEIN CONTENT IN SLOW AND FAST TWITCH MUSCLES OF DIABETIC RATS

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Keywords

ATROPHYQ1

STZ INDUCED DIABETESQ2

RESISTANCE TRAININGQ2

IL-15Q2

SKELETAL MUSCLEQ2

Abstract

Introduction: Resistance exercise training represents an effective interventional strategy to augment muscle mass, strength, and function in diabetes. It has been demonstrated that IL-15 (Interleukin-15) can act as an anabolic factor for SKELETAL MUSCLE, influencing protein metabolism. It has also been suggested that IL-15 could regulate peripheral glucose metabolism. Our aim was to investigate whether RESISTANCE TRAINING has any effect on IL-15 expression and protein of SKELETAL MUSCLEs in rats with diabetes.Materials and Methods: Rats were divided into the control, the training, and the streptozotocin induced diabetic and diabetic training groups. Training groups performed RESISTANCE TRAINING exercise which consisted of climbing a 1 m ladder with weight added to the tail. IL-15 Gene expression of soleus and Flexor Hallucis Longus muscles was analyzed using real time. SKELETAL MUSCLE protein of IL-15 was measured by ELIZA method.Results: The results of this study indicate that RESISTANCE TRAINING provided an anabolic stimulus sufficient to maintain the Flexor Hallucis Longus muscle mass of the diabetic training group. IL-15 mRNA levels in soleus were increased in the diabetic training group. Protein levels of IL-15 increased in the training and diabetic training groups in both SKELETAL MUSCLEs.Conclusion: Having a high content of mitochondria and relying on an oxidative pathway, soleus muscle was found to be more affected by diabetes. The lack of correlation of IL-15 mRNA and protein levels is partly due to transcriptional and translational blocks, which are present in the IL-15 gene sequence.

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APA: Copy

MOLANOURI SHAMSI, M., MOHAMMAD HASSAN, Z., MAHDAVI, M., GHARAKHANLOU, R., BAGHERSAD, L., AZADMANESH, K., & EDALAT, R.. (2012). INFLUENCE OF RESISTANCE TRAINING ON IL-15 MRNA EXPRESSION AND THE PROTEIN CONTENT IN SLOW AND FAST TWITCH MUSCLES OF DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 14(2 (SN 62)), 185-192. SID. https://sid.ir/paper/27937/en

Vancouver: Copy

MOLANOURI SHAMSI M., MOHAMMAD HASSAN Z., MAHDAVI M., GHARAKHANLOU R., BAGHERSAD L., AZADMANESH K., EDALAT R.. INFLUENCE OF RESISTANCE TRAINING ON IL-15 MRNA EXPRESSION AND THE PROTEIN CONTENT IN SLOW AND FAST TWITCH MUSCLES OF DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;14(2 (SN 62)):185-192. Available from: https://sid.ir/paper/27937/en

IEEE: Copy

M. MOLANOURI SHAMSI, Z. MOHAMMAD HASSAN, M. MAHDAVI, R. GHARAKHANLOU, L. BAGHERSAD, K. AZADMANESH, and R. EDALAT, “INFLUENCE OF RESISTANCE TRAINING ON IL-15 MRNA EXPRESSION AND THE PROTEIN CONTENT IN SLOW AND FAST TWITCH MUSCLES OF DIABETIC RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 14, no. 2 (SN 62), pp. 185–192, 2012, [Online]. Available: https://sid.ir/paper/27937/en

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