مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

376
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

209
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EFFECT OF ACARBOSE ON IN VITRO INTESTINAL ABSORPTION OF MONOSACCHARIDES IN DIABETIC RATS

Pages

  40-43

Abstract

 Background - ACARBOSE is known to lower blood glucose concentration by functioning ‎as an a#-glycosidase inhibitor in the intestine. It is also suggested that ACARBOSE may ‎directly arrest the INTESTINAL ABSORPTION of hexoses. The purpose of the present study ‎was to further elucidate the normal INTESTINAL ABSORPTION of hexoses and the effect of ‎ACARBOSE on the rate of INTESTINAL ABSORPTION of monosaccharides in normal and ‎streptozocin-induced DIABETIC RATS‏.‏‎‎ Methods - Segments of small intestine, as everted sacs, from normal and DIABETIC RATS ‎were incubated in solutions of various concentrations of monosaccharides, with and ‎without ACARBOSE, at 37°C for 90 min and the sugar concentration was measured ‎before and after incubation. Student"s t-test with p < 0.05 was used to compare the ‎mean ± standard error of the mean values for INTESTINAL ABSORPTION rates of various ‎sugars in different groups of rats‎‏.‏ Results - The optimum effective dose of most sugars for INTESTINAL ABSORPTION was 100 ‎mg/dL and the best inhibitory dose of ACARBOSE was 1 mg/mL. The rate of intestinal ‎absorption of glucose and galactose in the presence of ACARBOSE was significantly ‎reduced in both normal and DIABETIC RATS, while fructose and sucrose absorption was ‎not affected significantly by ACARBOSE in DIABETIC RATS. Mannose absorption was not ‎affected significantly by ACARBOSE‏.‏‎‎ Conclusion - ACARBOSE directly arrested the INTESTINAL ABSORPTION of most hexoses at ‎different rates, probably due to different mechanisms involved in the intestinal ‎absorption of monosaccharides‏.‏

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MERAT, A., & SAHMANI, M.. (2003). EFFECT OF ACARBOSE ON IN VITRO INTESTINAL ABSORPTION OF MONOSACCHARIDES IN DIABETIC RATS. ARCHIVES OF IRANIAN MEDICINE, 6(1), 40-43. SID. https://sid.ir/paper/279815/en

    Vancouver: Copy

    MERAT A., SAHMANI M.. EFFECT OF ACARBOSE ON IN VITRO INTESTINAL ABSORPTION OF MONOSACCHARIDES IN DIABETIC RATS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2003;6(1):40-43. Available from: https://sid.ir/paper/279815/en

    IEEE: Copy

    A. MERAT, and M. SAHMANI, “EFFECT OF ACARBOSE ON IN VITRO INTESTINAL ABSORPTION OF MONOSACCHARIDES IN DIABETIC RATS,” ARCHIVES OF IRANIAN MEDICINE, vol. 6, no. 1, pp. 40–43, 2003, [Online]. Available: https://sid.ir/paper/279815/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button