PULSE CYCLOPHOSPHAMIDE IN OCULAR MANIFESTATIONS OF BEHCET’S DISEASE: A DOUBLE BLIND CONTROLLED CROSSOVER STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DAVATCHI F.; SHAHRAM F.; CHAMS H.; AKBARIAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2004 | Volume:7 | Issue:3 Page(s): 201-205

Download Full-Text

View:

397

Download:

330

Cites:

Information Journal Paper

Title

PULSE CYCLOPHOSPHAMIDE IN OCULAR MANIFESTATIONS OF BEHCET’S DISEASE: A DOUBLE BLIND CONTROLLED CROSSOVER STUDY

Author(s)

DAVATCHI F. | SHAHRAM F. | CHAMS H. | AKBARIAN M. | Issue Writer Certificate

Keywords

BEHCET*S DISEASE · OCULAR LESIONS · PULSE CYCLOPHOSPHAMIDE

Abstract

Background –The ocular lesions of Behcet’s disease (BD) naturally progress toward severe loss of vision or blindness. Cytotoxic drugs are the main treatment. To the best of our knowledge, no controlled study has ever been performed to show their efficacy. This study was designed to evaluate the short-term efficacy of intravenous pulse cyclophosphamide (PCP). Methods – In a randomized double blind controlled crossover study, 35 consecutive patients meeting both the International and Classification Tree criteria for BD and suffering from active posterior uveitis and/or retinal vasculitis were randomly assigned to either PCP or placebo group. Both groups received prednisolone (0.5 mg/kg/day). PCP was administered as 1 g per square meter of the body surface once monthly to the PCP group and normal saline to the placebo group. After 3 months, the two groups were interchanged. Disease activity index (DAI) and visual acuity (VA) were calculated. The study was done at Behcet’s Unit, Rheumatology Research Center, Tehran University of Medical Sciences after approval of the Ethics Committee and patients’ consent Results – The mean VA improved from 3.7 to 4.9 (t = 3.309, p < 0.002) in the PCP group and from 4.4 to 4.5 (t = 0.317, p = 0.75) in the placebo group. The difference was significant (t = 2.402, p < 0.02). Other parameters improved more remarkably in the PCP group than in the placebo group, but differences were not statistically significant Conclusion – This study shows the efficacy of the combination of PCP and prednisolone over prednisolone alone.

Cites

No record.

References

No record.

Cite

APA: Copy

DAVATCHI, F., SHAHRAM, F., CHAMS, H., & AKBARIAN, M.. (2004). PULSE CYCLOPHOSPHAMIDE IN OCULAR MANIFESTATIONS OF BEHCET’S DISEASE: A DOUBLE BLIND CONTROLLED CROSSOVER STUDY. ARCHIVES OF IRANIAN MEDICINE, 7(3), 201-205. SID. https://sid.ir/paper/279836/en

Vancouver: Copy

DAVATCHI F., SHAHRAM F., CHAMS H., AKBARIAN M.. PULSE CYCLOPHOSPHAMIDE IN OCULAR MANIFESTATIONS OF BEHCET’S DISEASE: A DOUBLE BLIND CONTROLLED CROSSOVER STUDY. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2004;7(3):201-205. Available from: https://sid.ir/paper/279836/en

IEEE: Copy

F. DAVATCHI, F. SHAHRAM, H. CHAMS, and M. AKBARIAN, “PULSE CYCLOPHOSPHAMIDE IN OCULAR MANIFESTATIONS OF BEHCET’S DISEASE: A DOUBLE BLIND CONTROLLED CROSSOVER STUDY,” ARCHIVES OF IRANIAN MEDICINE, vol. 7, no. 3, pp. 201–205, 2004, [Online]. Available: https://sid.ir/paper/279836/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops