INACTIVATION OF POLIOVIRUS TYPE-1 AND HSV-1
IN HUMAN COAGULATION FACTOR VII
CONCENTRATE BY PASTEURIZATION

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REZVAN H.; NASIRI S.; MOUSAVI K.

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Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2001 | Volume:4 | Issue:1 Page(s): 10-13

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Title

INACTIVATION OF POLIOVIRUS TYPE-1 AND HSV-1 IN HUMAN COAGULATION FACTOR VII CONCENTRATE BY PASTEURIZATION

Author(s)

REZVAN H. | NASIRI S. | MOUSAVI K. | Issue Writer Certificate

Keywords

FACTOR VII • VIRAL INACTIVATION • PASTEURIZATION

Abstract

Background-Pasteurization is now available to treat products derived from plasma to inactivate transfusion-transmitted enveloped and non-enveloped viruses. Objective-This study was performed to assess the capacity and efficacy of virus inactivation by pasteurization in human coagulation factor VII concentrate with two model viruses including poliovirus type 1 (non-enveloped) and herpes simplex virus type 1 (enveloped). Methods-The viruses were added to the stabilized factor VII (70% sucrose, 20% glycine) and pasteurized for 10 h at 60° C. Viral infectivity was tested in vitro on cell culture (Vero) using standard microtitration assays and the virus titer was expressed as log10 TCID50/ml. Results-On completion of the pasteurization procedure, 6.3 log of poliovirus type 1 and 5.8 log of HSV-1 were inactivated. Recovery of factor VII activity using sucrose/glycine as stabilizer was 80%. Other stabilizers showed lower recovery of factor VII and were less suitable. Conclusion-Viral inactivation by pasteurization procedures destroys both enveloped and non-enveloped viruses and can be applied to production of factor VII from plasma with relatively good recovery and can improve the safety of replacement therapy in hemophilia patients with inhibitors.

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APA: Copy

REZVAN, H., NASIRI, S., & MOUSAVI, K.. (2001). INACTIVATION OF POLIOVIRUS TYPE-1 AND HSV-1 IN HUMAN COAGULATION FACTOR VII CONCENTRATE BY PASTEURIZATION. ARCHIVES OF IRANIAN MEDICINE, 4(1), 10-13. SID. https://sid.ir/paper/279863/en

Vancouver: Copy

REZVAN H., NASIRI S., MOUSAVI K.. INACTIVATION OF POLIOVIRUS TYPE-1 AND HSV-1 IN HUMAN COAGULATION FACTOR VII CONCENTRATE BY PASTEURIZATION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2001;4(1):10-13. Available from: https://sid.ir/paper/279863/en

IEEE: Copy

H. REZVAN, S. NASIRI, and K. MOUSAVI, “INACTIVATION OF POLIOVIRUS TYPE-1 AND HSV-1 IN HUMAN COAGULATION FACTOR VII CONCENTRATE BY PASTEURIZATION,” ARCHIVES OF IRANIAN MEDICINE, vol. 4, no. 1, pp. 10–13, 2001, [Online]. Available: https://sid.ir/paper/279863/en

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