PROTECTIVE PROPERTY OF CICHORIUM INTYBUS IN CCL4 INDUCED LIVER DAMAGE IN MICE

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KALANTARI H.A.; RASTMANESH R.

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Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2000 | Volume:3 | Issue:1 Page(s): 0-0

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Title

PROTECTIVE PROPERTY OF CICHORIUM INTYBUS IN CCL4 INDUCED LIVER DAMAGE IN MICE

Author(s)

KALANTARI H.A. | RASTMANESH R. | Issue Writer Certificate

Keywords

CICHORIUM INTYBUS • CCL4 • LIVER PROTECTION

Abstract

Background- Medicinal plants play an important role in pharmaceutical preparations and medicine. Cichorium intybus has its own value in traditional therapy. Objective-In this study we tried to find out the most effective dose and suitable time of administration for optimum results. Methods-Doses of 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg, 125 mg/kg and 150 mg/kg were administered orally to the test group. The positive control group also received CCl4 and the negative control group received normal saline. In this investigation serum enzyme activities such as ALT and AST were measured and the histopathological examinations were also studied. Results-The maximum effective dose was 75 mg/kg. Histopathological findings and enzyme levels showed that the best protective effect was seen when given within 30 minutes after CCl4 toxicity. Conclusion-In mice, liver protection was observed at various doses of Cichorium intybus but optimum protection was seen with a dose of 75 mg/kg given 30 minutes after CCl4 intoxication.

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APA: Copy

KALANTARI, H.A., & RASTMANESH, R.. (2000). PROTECTIVE PROPERTY OF CICHORIUM INTYBUS IN CCL4 INDUCED LIVER DAMAGE IN MICE. ARCHIVES OF IRANIAN MEDICINE, 3(1), 0-0. SID. https://sid.ir/paper/279982/en

Vancouver: Copy

KALANTARI H.A., RASTMANESH R.. PROTECTIVE PROPERTY OF CICHORIUM INTYBUS IN CCL4 INDUCED LIVER DAMAGE IN MICE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2000;3(1):0-0. Available from: https://sid.ir/paper/279982/en

IEEE: Copy

H.A. KALANTARI, and R. RASTMANESH, “PROTECTIVE PROPERTY OF CICHORIUM INTYBUS IN CCL4 INDUCED LIVER DAMAGE IN MICE,” ARCHIVES OF IRANIAN MEDICINE, vol. 3, no. 1, pp. 0–0, 2000, [Online]. Available: https://sid.ir/paper/279982/en

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