GENERATION OF IL-8 AND TNF-ALPHA IN PLATELET CONCENTRATES DURING STORAGE

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SHAIGAN MOZHGAN; POURFATH ELAH A.A.; NAMIRI M.; BABAEE GH.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2006 | Volume:9 | Issue:1 Page(s): 61-64

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Title

GENERATION OF IL-8 AND TNF-ALPHA IN PLATELET CONCENTRATES DURING STORAGE

Author(s)

SHAIGAN MOZHGAN | POURFATH ELAH A.A. | NAMIRI M. | BABAEE GH. | Issue Writer Certificate

Keywords

FEBRILE NONHEMOLYTIC TRANSFUSION REACTIONS (FNHTRS) • IL-1 BETA • IL-6 • IL-8 • TNF-ALPHA

Abstract

Background: Platelet transfusion is accompanied by febrile nonhemolytic transfusion reactions. The generation of cytokines (like IL-1 beta, IL-6, IL-8, and TNF-alpha) in platelet concentrates by white cells is suggested to be responsible for febrile nonhemolytic transfusion reactions. The number of white cells in the platelet concentrates is crucial to cytokine generation.Methods: This study was performed to determine whether WBC reduction in platelet concentrates by prestorage leukodepletion filters or inactivation by gamma radiation reduced the levels of these cytokines during storage for 3 days. Each of the platelet concentrates (n = 54) was prepared from a single random donor by platelet-rich plasma. This was then divided into four groups: 1) unfiltered, nonirradiated random-donner platelet concentrates (n = 13); 2) unfiltered, gamma-irradiated random-donner platelet concentrates (n = 16); 3) filtered, nonirradiated randomdonner platelet concentrates (n = 14); and 4) filtered, gamma-irradiated random-donner platelet concentrates (n = 11).Cytokine levels in platelet concentrates supernatants were measured by ELISA kits according to the manufacturer’s recommendations.Results: Our results showed that IL-8 was detected in unfiltered, nonirradiated, and gammairradiated random-donner platelet concentrates but not in the filtered random-donner platelet concentrates. TNF-alpha was only detected in unfiltered, nonirradiated units. Compared with unfiltered platelet concentrates, prestorage filtration prevented a rise in the IL-8 and TNF-alpha on day 3 of storage. The concentration of IL-1 beta was lower than the minimum concentration value of the kit used for this purpose. IL-6 was detected only in 7 units of all filtered platelet concentrates on day 3.Conclusion: These data indicate that gamma irradiation can not prevent generation of IL-8 in platelet concentrates during storage, but prestorage leukoreduction of platelet concentrates can prevent accumulation of IL-6, IL-8, and TNF-alpha during storage.

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APA: Copy

SHAIGAN, MOZHGAN, POURFATH ELAH, A.A., NAMIRI, M., & BABAEE, GH.. (2006). GENERATION OF IL-8 AND TNF-ALPHA IN PLATELET CONCENTRATES DURING STORAGE. ARCHIVES OF IRANIAN MEDICINE, 9(1), 61-64. SID. https://sid.ir/paper/280059/en

Vancouver: Copy

SHAIGAN MOZHGAN, POURFATH ELAH A.A., NAMIRI M., BABAEE GH.. GENERATION OF IL-8 AND TNF-ALPHA IN PLATELET CONCENTRATES DURING STORAGE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2006;9(1):61-64. Available from: https://sid.ir/paper/280059/en

IEEE: Copy

MOZHGAN SHAIGAN, A.A. POURFATH ELAH, M. NAMIRI, and GH. BABAEE, “GENERATION OF IL-8 AND TNF-ALPHA IN PLATELET CONCENTRATES DURING STORAGE,” ARCHIVES OF IRANIAN MEDICINE, vol. 9, no. 1, pp. 61–64, 2006, [Online]. Available: https://sid.ir/paper/280059/en

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