THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION

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AHMADI SEYED ALI; BOROUMAND M.A.; GOUHARI MOGHADAM K.; TAJIK PARVIN; DIBAJ S.M.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2008 | Volume:11 | Issue:3 Page(s): 318-321

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Title

THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION

Author(s)

Keywords

CHOLESTEROL

HDL

LDL

TRIGLYCERIDE

Abstract

Most clinical laboratories directly measure serum TRIGLYCERIDE, total CHOLESTEROL, and highdensity lipoprotein CHOLESTEROL. They indirectly calculate low-density lipoprotein CHOLESTEROL value using the Friedewald equation. Although high serum TRIGLYCERIDE (>400 mg/dL or 4.52 mmol/L) devaluates low- density lipoprotein CHOLESTEROL calculation by using this formula, effects of low serum TRIGLYCERIDE (<100 mg/dL or 1.13 mmol/L) on its accuracy is less defined.Two hundred thirty serum samples were assayed during a one-year period. In 115 samples, the TRIGLYCERIDE level was below 100 mg/dL and in 115 samples from age- and sex-matched patients the TRIGLYCERIDE level was 150 – 350 mg/dL (1.69 – 3.95 mmol/L). In both groups total CHOLESTEROL was above 250 mg/dL (6.46 mmol/L). On each sample, total CHOLESTEROL, high-density lipoprotein CHOLESTEROL, and TRIGLYCERIDE were directly measured in duplicate and low-density lipoprotein CHOLESTEROL measured directly and calculated with Friedewald equation as well.Statistical analysis showed that when TRIGLYCERIDE is <100 mg/dL, calculated low- density lipoprotein CHOLESTEROL is significantly overestimated (average :12.17 mg/dL or 0.31 mmol/L), where as when TRIGLYCERIDE is between 150 and 300 mg/dL no significant difference between calculated and measured low-density lipoprotein CHOLESTEROL is observed.In patients with low serum TRIGLYCERIDE and undesirably high total CHOLESTEROL levels, Friedewald equation may overestimate low-density lipoprotein CHOLESTEROL concentration and it should be either directly assayed or be calculated by a modified Friedewald equation. Using linear regression modeling, we propose a modified equation.

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APA: Copy

AHMADI, SEYED ALI, BOROUMAND, M.A., GOUHARI MOGHADAM, K., TAJIK, PARVIN, & DIBAJ, S.M.. (2008). THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION. ARCHIVES OF IRANIAN MEDICINE, 11(3), 318-321. SID. https://sid.ir/paper/280332/en

Vancouver: Copy

AHMADI SEYED ALI, BOROUMAND M.A., GOUHARI MOGHADAM K., TAJIK PARVIN, DIBAJ S.M.. THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2008;11(3):318-321. Available from: https://sid.ir/paper/280332/en

IEEE: Copy

SEYED ALI AHMADI, M.A. BOROUMAND, K. GOUHARI MOGHADAM, PARVIN TAJIK, and S.M. DIBAJ, “THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION,” ARCHIVES OF IRANIAN MEDICINE, vol. 11, no. 3, pp. 318–321, 2008, [Online]. Available: https://sid.ir/paper/280332/en

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