مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

TOPICAL MITOMYCIN-C FOR TREATMENT OF PARTIALLY-EXCISED OCULAR SURFACE SQUAMOUS NEOPLASIA

Pages

  55-59

Abstract

 Background: This study was conducted to determine the treatment outcome of incompletely removed, histopathologically documented OCULAR SURFACE SQUAMOUS NEOPLASIA with MITOMYCIN-C. Methods: Through an interventional case series, 17 eyes of 17 patients presented with incompletely removed OCULAR SURFACE SQUAMOUS NEOPLASIA were treated according to a protocol using two to three alternate seven-day courses of 0.04% MITOMYCIN-C. Clinical recurrence was retreated with the same protocol. All patients had weekly follow-up visits to the end of the treatment course, then biweekly visits for three months, and monthly visits, thereafter.Results: The mean±SD follow-up period was 30.76±4.4 (range: 24.5 – 41) months. Five patients (29.4%) experienced recurrence after the initial treatment; four of them responded to retreatment and were disease-free till the end of follow-up. Survival analysis with Kaplan-Meier method was performed. Taking into account four recurrences, the 41-month nonrecurrence rate was 70.6%. However, including four of five patients with recurrence who responded to retreatment, the final outcome in survival analysis was 94.1% nonrecurrence for 41 months of follow-up.All patients reported mild to moderate redness and irritation which were controlled with lubricants and mild corticosteroid eye drops. No serious ocular or systemic side effects were observed.Conclusion: Point zero four percent (0.04%) MITOMYCIN-C drop used as two to three alternate seven-day courses seems to be a safe and effective treatment for OCULAR SURFACE SQUAMOUS NEOPLASIA.

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    Cite

    APA: Copy

    RAHIMI, F., ALI POUR, F., GHAZIZADEH HASHEMI, H., HASHEMIAN, M.N., MEHRDAD, R., & SALEH SADEGHPOUR, BAHRAM. (2009). TOPICAL MITOMYCIN-C FOR TREATMENT OF PARTIALLY-EXCISED OCULAR SURFACE SQUAMOUS NEOPLASIA. ARCHIVES OF IRANIAN MEDICINE, 12(1), 55-59. SID. https://sid.ir/paper/280381/en

    Vancouver: Copy

    RAHIMI F., ALI POUR F., GHAZIZADEH HASHEMI H., HASHEMIAN M.N., MEHRDAD R., SALEH SADEGHPOUR BAHRAM. TOPICAL MITOMYCIN-C FOR TREATMENT OF PARTIALLY-EXCISED OCULAR SURFACE SQUAMOUS NEOPLASIA. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2009;12(1):55-59. Available from: https://sid.ir/paper/280381/en

    IEEE: Copy

    F. RAHIMI, F. ALI POUR, H. GHAZIZADEH HASHEMI, M.N. HASHEMIAN, R. MEHRDAD, and BAHRAM SALEH SADEGHPOUR, “TOPICAL MITOMYCIN-C FOR TREATMENT OF PARTIALLY-EXCISED OCULAR SURFACE SQUAMOUS NEOPLASIA,” ARCHIVES OF IRANIAN MEDICINE, vol. 12, no. 1, pp. 55–59, 2009, [Online]. Available: https://sid.ir/paper/280381/en

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