مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

PRE- AND POST-TREATMENT OF STREPTOZOCIN ADMINISTERED RATS WITH MELATONIN: EFFECTS ON SOME HEPATIC ENZYMES OF CARBOHYDRATE METABOLISM

Pages

  105-110

Abstract

 Background: MELATONIN, found in high concentrations in the pineal gland, organs within the digestive system and in some plants and fungi, acts as an antioxidant which decreases reactive oxygen species in streptozocin-induced diabetic rats, raises insulin secretion by the pancreatic b-cells and increases the number of insulin receptors on hepatocyte membranes.Materials and Methods: The protective and therapeutic effects of MELATONIN feeding in streptozocin-induced diabetic rats were studied. Streptozocin administered rats were gavaged with MELATONIN, pre- and post-treatment, at a level of 5 mg/kg body weight daily for a period of 15 days.Levels of plasma glucose, cholesterol, triacylglycerol, oral glucose tolerance test, and some hepatic enzymes of carbohydrate metabolism including insulin inducible GLUCOKINASE, HEXOKINASE and glucose 6-P dehydrogenase were measured using standard methods and compared with the values in normoglycemic and diabetic control groups.Results: Both pre- and post-treatment of the streptozocin administered rats with MELATONIN normalized plasma glucose, cholesterol, and triacylglycerol, improved oral glucose tolerance test and increased hepatic GLUCOKINASE, HEXOKINASE and glucose 6-P dehydrogenase specific activities to the levels seen in normal rats.Conclusion: MELATONIN pre-treatment prevents the injurious effects of streptozocin in rats. In streptozocin induced diabetic animals, post-treatment with this antioxidant normalizes both blood and LIVER constituents which were ameliorated by streptozocin.

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    APA: Copy

    AKMALI, M., AHMADI, ROBAB, & VESAL, M.. (2010). PRE- AND POST-TREATMENT OF STREPTOZOCIN ADMINISTERED RATS WITH MELATONIN: EFFECTS ON SOME HEPATIC ENZYMES OF CARBOHYDRATE METABOLISM. ARCHIVES OF IRANIAN MEDICINE, 13(2), 105-110. SID. https://sid.ir/paper/280544/en

    Vancouver: Copy

    AKMALI M., AHMADI ROBAB, VESAL M.. PRE- AND POST-TREATMENT OF STREPTOZOCIN ADMINISTERED RATS WITH MELATONIN: EFFECTS ON SOME HEPATIC ENZYMES OF CARBOHYDRATE METABOLISM. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2010;13(2):105-110. Available from: https://sid.ir/paper/280544/en

    IEEE: Copy

    M. AKMALI, ROBAB AHMADI, and M. VESAL, “PRE- AND POST-TREATMENT OF STREPTOZOCIN ADMINISTERED RATS WITH MELATONIN: EFFECTS ON SOME HEPATIC ENZYMES OF CARBOHYDRATE METABOLISM,” ARCHIVES OF IRANIAN MEDICINE, vol. 13, no. 2, pp. 105–110, 2010, [Online]. Available: https://sid.ir/paper/280544/en

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