TOPOGRAPHY OF GASTRITIS AND ITS SEVERITY IN 864 FIRST DEGREE RELATIVES OF GASTRIC CANCER PATIENTS

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ZENDEHDEL N.; MASARAT S.; SHEYKH ALESLAMI A.; RAKHSHANI N.; SAEIDI S.; RAFIEI R.; NOUBAKHT H.; TABIB S.M.; SALIMINEZHAD MEHRDAD; DOUGHAEI MOGHADAM M.; NASIRI J.; AZIMI K.; FAKHAR R.; BABAEI MAHDI; DIDEHVAR R.; MOHAMMADI N.A.; TAVAZOUEI M.; MALEKZADEH R.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2010 | Volume:13 | Issue:6 Page(s): 469-475

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Title

TOPOGRAPHY OF GASTRITIS AND ITS SEVERITY IN 864 FIRST DEGREE RELATIVES OF GASTRIC CANCER PATIENTS

Author(s)

Keywords

FAMILIAL

GASTRIC CANCER

GASTRITIS

H. PYLORI

Abstract

Objectives: Studies on gastric mucosal histological findings among first degree relatives (FDR) of GASTRIC CANCER (GC) patients are scarce. The aim is to evaluate the topography and the severity of GASTRITIS among FDR of GC patients. Design: A total of 989 subjects who were FDR of GC patients, ages 40 – 65 years underwent gastroscopies. When no gross lesion was found, five specimens were evaluated according to the Sydney Classification and one for urease testing in order to determine the type of GASTRITIS and its severity.Results: Of the 989 subjects, 107 had significant lesions, including two with GC and one with esophageal cancer. The 864 subjects who had complete morphological data taken from five gastric areas (two from the antrum and three from the corpus) comprised 419 males (mean age 48.5±7 years) and 445 females (mean age 47±6.4 years). The H. PYLORI rate was 76.6%. Normal mucosa was seen in 6.9%, antrum-restricted GASTRITIS in 7.4%, antrum-predominant GASTRITIS in 63.5% and corpus-predominant GASTRITIS in 20% (both had >80% H. PYLORI infection) and corpus-restricted GASTRITIS in 2%. More atrophy was seen in the antrum and corpus of FDR females than males. The severity did not differ between those with one or more GC patients’ relatives. Forty-nine percent of FDR had atrophy and 9.4% intestinal metaplasia (IM) in the corpus. After the age of 40, there was progression of intestinal metaplasia from 12.2 to 27.3% in the antrum and from 6.7% to 26.2% in the corpus during two decades. No high grade dysplasia was found in this mid-age population.Conclusion: Only one-fifth of FDR have H. PYLORI-induced corpus-predominant GASTRITIS who are at risk for cancer and suitable for eradication. Corpus-restricted GASTRITIS is a rare disease in this area.

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APA: Copy

ZENDEHDEL, N., MASARAT, S., SHEYKH ALESLAMI, A., RAKHSHANI, N., SAEIDI, S., RAFIEI, R., NOUBAKHT, H., TABIB, S.M., SALIMINEZHAD, MEHRDAD, DOUGHAEI MOGHADAM, M., NASIRI, J., AZIMI, K., FAKHAR, R., BABAEI, MAHDI, DIDEHVAR, R., MOHAMMADI, N.A., TAVAZOUEI, M., & MALEKZADEH, R.. (2010). TOPOGRAPHY OF GASTRITIS AND ITS SEVERITY IN 864 FIRST DEGREE RELATIVES OF GASTRIC CANCER PATIENTS. ARCHIVES OF IRANIAN MEDICINE, 13(6), 469-475. SID. https://sid.ir/paper/280635/en

Vancouver: Copy

ZENDEHDEL N., MASARAT S., SHEYKH ALESLAMI A., RAKHSHANI N., SAEIDI S., RAFIEI R., NOUBAKHT H., TABIB S.M., SALIMINEZHAD MEHRDAD, DOUGHAEI MOGHADAM M., NASIRI J., AZIMI K., FAKHAR R., BABAEI MAHDI, DIDEHVAR R., MOHAMMADI N.A., TAVAZOUEI M., MALEKZADEH R.. TOPOGRAPHY OF GASTRITIS AND ITS SEVERITY IN 864 FIRST DEGREE RELATIVES OF GASTRIC CANCER PATIENTS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2010;13(6):469-475. Available from: https://sid.ir/paper/280635/en

IEEE: Copy

N. ZENDEHDEL, S. MASARAT, A. SHEYKH ALESLAMI, N. RAKHSHANI, S. SAEIDI, R. RAFIEI, H. NOUBAKHT, S.M. TABIB, MEHRDAD SALIMINEZHAD, M. DOUGHAEI MOGHADAM, J. NASIRI, K. AZIMI, R. FAKHAR, MAHDI BABAEI, R. DIDEHVAR, N.A. MOHAMMADI, M. TAVAZOUEI, and R. MALEKZADEH, “TOPOGRAPHY OF GASTRITIS AND ITS SEVERITY IN 864 FIRST DEGREE RELATIVES OF GASTRIC CANCER PATIENTS,” ARCHIVES OF IRANIAN MEDICINE, vol. 13, no. 6, pp. 469–475, 2010, [Online]. Available: https://sid.ir/paper/280635/en

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