COMPARATIVE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES OF DRY TYPE CUTANEOUS LEISHMANIASIS AFTER ADMINISTRATION OF MEGLUMINE ANTIMONIATE, IMIQUIMOD OR COMBINATION THERAPY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAMSI MEYMANDI SIMIN; JAVADI ABDOLREZA; DABIRI SHAHRIAR; SHAMSI MEYMANDI MANZOOMEH; NADJI MEHRDAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2011 | Volume:14 | Issue:4 Page(s): 238-243

Download Full-Text

View:

289

Download:

Cites:

Information Journal Paper

Title

COMPARATIVE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES OF DRY TYPE CUTANEOUS LEISHMANIASIS AFTER ADMINISTRATION OF MEGLUMINE ANTIMONIATE, IMIQUIMOD OR COMBINATION THERAPY

Author(s)

Keywords

CD3

CD20

CD1A

CD68

CUTANEOUS LEISHMANIASIS

IMIQUIMOD

MEGLUMINE ANTIMONIATE

Abstract

Background: This study compared histological and immunohistochemical changes of CUTANEOUS LEISHMANIASIS treated with MEGLUMINE ANTIMONIATE, IMIQUIMOD, and the combination of both therapies.Methods: Single blind clinicopathological studies of fifteen patients with old world CUTANEOUS LEISHMANIASIS in Kerman, Iran were included.A total of four patients received a combination of IMIQUIMOD (5% cream) and intra-lesional MEGLUMINE ANTIMONIATE weekly for four weeks.Monotherapy with IMIQUIMOD was given to seven patients and four patients were treated with MEGLUMINE ANTIMONIATE intralesionally. Histological confirmation was performed before and during therapy. Semi-quantitative histological parameters such as numbers of mixed inflammatory cells (cells/mm2) and percentages of Langerhans cells (CD1a+), T-cells (CD3+), B-cells (CD20+), and macrophages (CD68+) were calculated immunohistochemically in the dermis and adjacent epidermis.Results: Topical IMIQUIMOD significantly reduced mean histiocytic cellular aggregation size (P<0.05). MEGLUMINE ANTIMONIATE reduced parasite load and infected activated histiocytes in the dermis (P<0.05). MEGLUMINE ANTIMONIATE therapy decreased epidermal CD3+ lymphocytes but increased them in the dermis, within the granulomas (P<0.05). During topical application of IMIQUIMOD a depletion of CD1A+ dendritic cells in the epidermis (P<0.05) and slight predominance of dendritic cells in the dermis were observed. Combined therapy and IMIQUIMOD monotherapy decreased CD68+macrophages in the dermis (P<0.05).Conclusion: MEGLUMINE ANTIMONIATE decreases parasite load with considerable effect on up-regulation of T-cells, which demonstrates that MEGLUMINE ANTIMONIATE works as parasitocidal and immunomodulator, which could be a first line of treatment. IMIQUIMOD, as an immunomodulator, accentuates the host immune response and reduces granuloma size which could be effective immunomodulator for combination therapy. Monotherapy of IMIQUIMOD is less effective than the two other regimens in decreasing parasite load, inflammation and congestion at the inoculated site.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAMSI MEYMANDI, SIMIN, JAVADI, ABDOLREZA, DABIRI, SHAHRIAR, SHAMSI MEYMANDI, MANZOOMEH, & NADJI, MEHRDAD. (2011). COMPARATIVE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES OF DRY TYPE CUTANEOUS LEISHMANIASIS AFTER ADMINISTRATION OF MEGLUMINE ANTIMONIATE, IMIQUIMOD OR COMBINATION THERAPY. ARCHIVES OF IRANIAN MEDICINE, 14(4), 238-243. SID. https://sid.ir/paper/280656/en

Vancouver: Copy

SHAMSI MEYMANDI SIMIN, JAVADI ABDOLREZA, DABIRI SHAHRIAR, SHAMSI MEYMANDI MANZOOMEH, NADJI MEHRDAD. COMPARATIVE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES OF DRY TYPE CUTANEOUS LEISHMANIASIS AFTER ADMINISTRATION OF MEGLUMINE ANTIMONIATE, IMIQUIMOD OR COMBINATION THERAPY. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(4):238-243. Available from: https://sid.ir/paper/280656/en

IEEE: Copy

SIMIN SHAMSI MEYMANDI, ABDOLREZA JAVADI, SHAHRIAR DABIRI, MANZOOMEH SHAMSI MEYMANDI, and MEHRDAD NADJI, “COMPARATIVE HISTOLOGICAL AND IMMUNOHISTOCHEMICAL CHANGES OF DRY TYPE CUTANEOUS LEISHMANIASIS AFTER ADMINISTRATION OF MEGLUMINE ANTIMONIATE, IMIQUIMOD OR COMBINATION THERAPY,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 4, pp. 238–243, 2011, [Online]. Available: https://sid.ir/paper/280656/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops