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Information Journal Paper

Title

FIVE-YEAR FOLLOW-UP OF THE LOCAL AUTOLOGOUS TRANSPLANTATION OF CD133+ ENRICHED BONE MARROW CELLS IN PATIENTS WITH MYOCARDIAL INFARCTION

Pages

  32-35

Keywords

CD133+ CELLS 

Abstract

 Background: The implantation of a CD133+bone marrow cell population into an ischemic myocardium has emerged as a promising therapeutic modality for myocardial regeneration and restoration of ventricular contractility. While previous studies have documented the short-term safety and efficacy of CD133+cell TRANSPLANTATION in patients with acute MYOCARDIAL INFARCTION, there are few reports of long-term follow-up results. Here, we present the results of long-term follow-up of our acute MYOCARDIAL INFARCTION patients who were treated with intramyocardial injection of CD133+cells after coronary bypass graft.Methods: After five years, 13 patients in the cell TRANSPLANTATION group and 5 patients in the control group underwent safety and efficacy investigations by New York Heart Association classification and two-dimensional echocardiography (2D echo).Results: During the five-year study period, no major cardiac adverse events were reported among patients who received CD133+stem cells. Regarding efficiency, we observed no statistically significant treatment effects for the echocardiographic parameters [left ventricular end-diastolic and end-systolic volumes, and resting ejection fraction] measured during the follow-up period. However, detailed analysis of regional wall motion revealed an improvement in the Wall Motion Score Index from baseline to the six month follow-up, which was maintained during the follow-up period.Conclusion: Taken together, the long-term results of the present study indicate that TRANSPLANTATION of CD133+is a safe and feasible procedure; however, we could not show any major benefits in our patients. Thus, this issue needs to be addressed by conducting other studies with more patients.

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    APA: Copy

    AHMADI, HOSSEIN, MOSHKANI FARAHANI, MARYAM, KOUHKAN, AZAM, MOAZZAMI, KASRA, FAZELI, ROGHAYEH, SADEGHIAN, HAKIMEH, NAMIRI, MEHRNAZ, MADANI CIVI, MANOUCHEHR, BAHARVAND, HOSSEIN, & AGHDAMI, NASSER. (2012). FIVE-YEAR FOLLOW-UP OF THE LOCAL AUTOLOGOUS TRANSPLANTATION OF CD133+ ENRICHED BONE MARROW CELLS IN PATIENTS WITH MYOCARDIAL INFARCTION. ARCHIVES OF IRANIAN MEDICINE, 15(1), 32-35. SID. https://sid.ir/paper/280774/en

    Vancouver: Copy

    AHMADI HOSSEIN, MOSHKANI FARAHANI MARYAM, KOUHKAN AZAM, MOAZZAMI KASRA, FAZELI ROGHAYEH, SADEGHIAN HAKIMEH, NAMIRI MEHRNAZ, MADANI CIVI MANOUCHEHR, BAHARVAND HOSSEIN, AGHDAMI NASSER. FIVE-YEAR FOLLOW-UP OF THE LOCAL AUTOLOGOUS TRANSPLANTATION OF CD133+ ENRICHED BONE MARROW CELLS IN PATIENTS WITH MYOCARDIAL INFARCTION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2012;15(1):32-35. Available from: https://sid.ir/paper/280774/en

    IEEE: Copy

    HOSSEIN AHMADI, MARYAM MOSHKANI FARAHANI, AZAM KOUHKAN, KASRA MOAZZAMI, ROGHAYEH FAZELI, HAKIMEH SADEGHIAN, MEHRNAZ NAMIRI, MANOUCHEHR MADANI CIVI, HOSSEIN BAHARVAND, and NASSER AGHDAMI, “FIVE-YEAR FOLLOW-UP OF THE LOCAL AUTOLOGOUS TRANSPLANTATION OF CD133+ ENRICHED BONE MARROW CELLS IN PATIENTS WITH MYOCARDIAL INFARCTION,” ARCHIVES OF IRANIAN MEDICINE, vol. 15, no. 1, pp. 32–35, 2012, [Online]. Available: https://sid.ir/paper/280774/en

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