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Information Journal Paper

Title

MODULATION OF WIN55, 212-2 STATE-DEPENDENT MEMORY BY α2-ADRENERGIC RECEPTORS OF THE DORSAL HIPPOCAMPUS

Pages

  389-395

Abstract

 Background: An overlapping distribution of 2-adrenergic receptors with cannabinoid receptors has been reported in certain brain structures such as the dorsal hippocampus. Thus, functional interactions between cannabinoid and 2-adrenergic systems in cognitive control seem possible. In the present study, we examine the possible role of 2-adrenergic receptors of the dorsal hippocampus on WIN55, 212-2 state-dependent learning.Methods: Adult male Wistar RATs were bilaterally implanted with chronic cannulae in the CA1 regions of their dorsal hippocampi trained in a step-down type inhibitory avoidance task and tested 24 hr after training, to measure step-down latency.Results: Post-training or pre-test intra-CA1 administration of the cannabinoid receptor agonist, WIN 55, 212-2 (0.25 and 0.5 mg/rat) induced amnesia. Amnesia produced by post-training WIN55, 212-2 (0.5 mg/rat) was reversed by pre-test administration of WIN55, 212-2, that was due to a state-dependent effect. Pre-test intra-CA1 microinjections of CLONIDINE (0.25, 0.5 and 1 mg/rat) or YOHIMBINE (0.5, 0.75, and 1 mg/rat) did not affect memory retrieval per se. Pre-test intra-CA1 administration of CLONIDINE (0.5 and 1 mg/rat) or CLONIDINE (0.25, 0.5, and 1 mg/rat) with an ineffective dose of WIN 55, 212-2 (0.25 mg/rat) reversed post-training WIN55, 212-2 (0.5 mg/rat, intra-CA1) induced memory impairment.Pre-test intra-CA1 microinjection of YOHIMBINE (1 mg/rat) before administration of WIN55, 212-2 (0.5 mg/rat, intra-CA1), however, dose dependently inhibited WIN55, 212-2 STATE-DEPENDENT MEMORY.Conclusion: Modulation of 2-adrenergic receptors in the dorsal hip pocampal CA1 regions can inuence WIN55, 212-2 induced amnesia and WIN55, 212-2 state-dependent learning of an inhibitory avoidance task by pre- or post-synaptic mechanism (s).

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    • Cite

    APA: Copy

    PIRI, MORTEZA, & ZARRINDAST, MOHAMMAD REZA. (2011). MODULATION OF WIN55, 212-2 STATE-DEPENDENT MEMORY BY α2-ADRENERGIC RECEPTORS OF THE DORSAL HIPPOCAMPUS. ARCHIVES OF IRANIAN MEDICINE, 14(6), 389-395. SID. https://sid.ir/paper/280797/en

    Vancouver: Copy

    PIRI MORTEZA, ZARRINDAST MOHAMMAD REZA. MODULATION OF WIN55, 212-2 STATE-DEPENDENT MEMORY BY α2-ADRENERGIC RECEPTORS OF THE DORSAL HIPPOCAMPUS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2011;14(6):389-395. Available from: https://sid.ir/paper/280797/en

    IEEE: Copy

    MORTEZA PIRI, and MOHAMMAD REZA ZARRINDAST, “MODULATION OF WIN55, 212-2 STATE-DEPENDENT MEMORY BY α2-ADRENERGIC RECEPTORS OF THE DORSAL HIPPOCAMPUS,” ARCHIVES OF IRANIAN MEDICINE, vol. 14, no. 6, pp. 389–395, 2011, [Online]. Available: https://sid.ir/paper/280797/en

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