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Title

OCCULT HEPATITIS B VIRUS INFECTION AMONG IRANIAN BLOOD DONORS: A PRELIMINARY STUDY

Pages

  106-107

Abstract

 BACKGROUND: Although serological screening tests for blood-borne hepatitis viruses have effectively reduced the risk of HBV transmission through transfusion of infected blood, there is still a possibility that infected blood units from occult carriers being released into the blood supply.The aim of this study was to determine the prevalence of ANTI-HBc among Iranian BLOOD DONORs and evaluate the presence of HBV DNA in HBSAG NEGATIVE plasma samples.MATERIALS AND METHODS: In the present study, 5000 HBSAG NEGATIVE samples were collected from donors in blood transfusion centers in Tehran. All HBSAG NEGATIVE samples were tested for the presence of ANTI-HBc ANTIbody and ANTI-HBs ANTIbody (HBsAb) using ELISA method. Also, all HBSAG NEGATIVE samples were tested for the presence of HBV DNA by real-time PCR.RESULTS: Four hundred ninety nine (9.98%) out of the 5000 HBSAG NEGATIVE BLOOD DONORs were ANTI-HBc positive. Out of 499 ANTI-HBc positive samples that were tested for ANTI-HBs, 394 (78.4%) were ANTI-HBs positive, and 275 (62.7%) had an ANTIbody titer greater than 100 IU/mL. HBV DNA was detected in two samples.CONCLUSION: In countries with intermediate rate of HBV infection like Iran, the prevalence of ANTI-HBc ANTIbody in HBSAG NEGATIVE BLOOD DONORs is found to be high. As a result, routine ANTI-HBc screening of HBsAg-negative BLOOD DONORs without complementary tests (ANTI-HBs / HBV-DNA) can limit the number of blood transfusions. Therefore, it might be better to include the detection of HBV DNA along with the routine tests.

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    APA: Copy

    ALIZADEH, ZAHRA, MILANI, SAEIDEH, & SHARIFI, ZOHREH. (2014). OCCULT HEPATITIS B VIRUS INFECTION AMONG IRANIAN BLOOD DONORS: A PRELIMINARY STUDY. ARCHIVES OF IRANIAN MEDICINE, 17(2), 106-107. SID. https://sid.ir/paper/280884/en

    Vancouver: Copy

    ALIZADEH ZAHRA, MILANI SAEIDEH, SHARIFI ZOHREH. OCCULT HEPATITIS B VIRUS INFECTION AMONG IRANIAN BLOOD DONORS: A PRELIMINARY STUDY. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2014;17(2):106-107. Available from: https://sid.ir/paper/280884/en

    IEEE: Copy

    ZAHRA ALIZADEH, SAEIDEH MILANI, and ZOHREH SHARIFI, “OCCULT HEPATITIS B VIRUS INFECTION AMONG IRANIAN BLOOD DONORS: A PRELIMINARY STUDY,” ARCHIVES OF IRANIAN MEDICINE, vol. 17, no. 2, pp. 106–107, 2014, [Online]. Available: https://sid.ir/paper/280884/en

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