OPIUM DECREASES THE AGE AT MYOCARDIAL INFARCTION AND SUDDEN CARDIAC DEATH: A LONG- AND SHORT-TERM OUTCOME EVALUATION

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ROOHAFZA HAMIDREZA; TALAEI MOHAMMAD; SADEGHI MASOUMEH; HAGHANI POONE; SHOKOUH PEDRAM; SARRAFZADEGAN NIZAL

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2013 | Volume:16 | Issue:3 Page(s): 154-160

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Title

OPIUM DECREASES THE AGE AT MYOCARDIAL INFARCTION AND SUDDEN CARDIAC DEATH: A LONG- AND SHORT-TERM OUTCOME EVALUATION

Author(s)

Keywords

COMPLICATIONS

MYOCARDIAL INFARCTION

OPIUM DEPENDENCE

RISK FACTOR

SUDDEN CARDIAC DEATH

Abstract

BACKGROUND: OPIUM DEPENDENCE is a recognized individual and public health threat, but little is known about its association with acute MYOCARDIAL INFARCTION (AMI) or SUDDEN CARDIAC DEATH (SCD).METHODS: In a cross-sectional study followed by a one-year matched longitudinal cohort, all 569 men hospitalized with AMI in all Cardiac Care Units (CCU) of Isfahan, Iran, were recruited in a six-month period. In addition, 123 out-of-hospital deaths were included that were diagnosed as SCD at the same duration. Among those discharged alive, 126 opium dependents were matched with 126 nondependents (mostly nonusers) according to age and smoking status, and were followed for one year. OPIUM DEPENDENCE was measured using the ICD10 criteria and Severity of Dependence Scale (SDS) questionnaire. The method was validated by morphine blood levels. Biochemical measurements, blood pressure, blood cell counts, anthropometrics, and ejection fraction were measured at baseline and repeated at the end of follow-up.RESULTS: There were 118 (17.1%) patients with an average of 17.4±10.4 years of abuse who met the criteria for opium dependency. OPIUM DEPENDENCE decreased the age at event by 3.6 (95% CI: 1.2-6.0) years and was independent of smoking (P=0.003). In terms of cardiovascular RISK FACTORs such as ejection fraction, in addition to post-AMI mortality and morbidity, no significant associations were noted at baseline or after one year of follow-up. The odds ratio of sustained smoking after AMI was 1.92 (95% CI: 1.04-3.52) in opium dependents (P=0.033).CONCLUSION: Despite public opinion, opium did not improve cardiovascular RISK FACTORs, or post-AMI mortality and morbidity. Conversely, there were irrefutable findings regarding the detrimental effects of OPIUM DEPENDENCE.

Cites

COMPARISON OF MYOCARDIAL INFARCTION OUTCOME IN OPIUM DEPENDENT AND NON-DEPENDENT PATIENTS

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APA: Copy

ROOHAFZA, HAMIDREZA, TALAEI, MOHAMMAD, SADEGHI, MASOUMEH, HAGHANI, POONE, SHOKOUH, PEDRAM, & SARRAFZADEGAN, NIZAL. (2013). OPIUM DECREASES THE AGE AT MYOCARDIAL INFARCTION AND SUDDEN CARDIAC DEATH: A LONG- AND SHORT-TERM OUTCOME EVALUATION. ARCHIVES OF IRANIAN MEDICINE, 16(3), 154-160. SID. https://sid.ir/paper/280939/en

Vancouver: Copy

ROOHAFZA HAMIDREZA, TALAEI MOHAMMAD, SADEGHI MASOUMEH, HAGHANI POONE, SHOKOUH PEDRAM, SARRAFZADEGAN NIZAL. OPIUM DECREASES THE AGE AT MYOCARDIAL INFARCTION AND SUDDEN CARDIAC DEATH: A LONG- AND SHORT-TERM OUTCOME EVALUATION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2013;16(3):154-160. Available from: https://sid.ir/paper/280939/en

IEEE: Copy

HAMIDREZA ROOHAFZA, MOHAMMAD TALAEI, MASOUMEH SADEGHI, POONE HAGHANI, PEDRAM SHOKOUH, and NIZAL SARRAFZADEGAN, “OPIUM DECREASES THE AGE AT MYOCARDIAL INFARCTION AND SUDDEN CARDIAC DEATH: A LONG- AND SHORT-TERM OUTCOME EVALUATION,” ARCHIVES OF IRANIAN MEDICINE, vol. 16, no. 3, pp. 154–160, 2013, [Online]. Available: https://sid.ir/paper/280939/en

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