ARE THE SERUM BIOMARKERS PEPSINOGEN I AND II GOOD PREDICTORS FOR THE DETECTION OF SUBJECTS WITH ATROPHIC GASTRITIS IN AREAS THAT HAVE DIFFERENT GASTRIC CANCER INCIDENCE?

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MOHAMADKHANI ASHRAF; MOGHADAM SODAIF DARVISH; SALMANROGHANI HASAN; ALLAF ASGHARI AMIN; YAZDANBOD ABBAS; MIRZAEI MAHBOUBEH; HAJ SHEYKHOLESLAMI ARGHAVAN; BASHIRI JAFAR; SADJADI ALIREZA; MASSARRAT SADEGH

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2013 | Volume:16 | Issue:4 Page(s): 208-212

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Title

ARE THE SERUM BIOMARKERS PEPSINOGEN I AND II GOOD PREDICTORS FOR THE DETECTION OF SUBJECTS WITH ATROPHIC GASTRITIS IN AREAS THAT HAVE DIFFERENT GASTRIC CANCER INCIDENCE?

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Keywords

BIOMARKER

GASTRIC CANCER

PEPSINOGEN I

PEPSINOGEN II

Abstract

Background: Northern Iran (Ardabil) is characterized by a high GASTRIC CANCER (GC) rate, whereas Southern Iran (Kerman and Yazd) has a low GC rate. The aim of this study is to verify the potential for PEPSINOGEN I and II to detect atrophic gastritis (AG) in both high and low risk populations for GC.Methods: Sera of blood donors and patients with GC from Ardebil, Kerman and Yazd were used to measure levels of PEPSINOGEN I, II and H. pylori IgG antibody. GC rates in these cities were determined according to the Cancer Registry and upper gastrointestinal (GI) endoscopy results.Results: There were 449 subjects with an average age of 45±15 years. The GC rate in the endoscopy units of the hospital in Ardabil was four times higher than Kerman or Yazd. The mean serum PEPSINOGEN I levels did not differ between Ardabil (102±42.6 mg/mL), Kerman (103.3±49.8 mg/mL), and Yazd (111.7±39 mg/mL). PEPSINOGEN II levels were: 8.1±4.7 mg/mL (Ardabil), 7.5±5.3 mg/mL (Kerman), and 7.6±4.4 mg/mL (Yazd), which were not different. The H. pylori infection rates were: Ardabil (61%), Kerman (55%), and Yazd (73%). A low ratio of PEPSINOGEN I to II (m3) was seen in Ardabil (1.3%), Kerman (1.9%), and Yazd (0.0%), which was not significant. A total of 51.9% of GC patients from Ardabil had normal PEPSINOGEN I ( ³70 mg/mL) levels and PEPSINOGEN I/II ratios that were>5.Conclusion: Serum BIOMARKERs PEPSINOGEN I and II and their ratios are probably not sensitive predictors of AG in areas that have either a high or low GC prevalence. This finding is likely related to the lack of an association between GC and advanced AG.

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APA: Copy

MOHAMADKHANI, ASHRAF, MOGHADAM, SODAIF DARVISH, SALMANROGHANI, HASAN, ALLAF ASGHARI, AMIN, YAZDANBOD, ABBAS, MIRZAEI, MAHBOUBEH, HAJ SHEYKHOLESLAMI, ARGHAVAN, BASHIRI, JAFAR, SADJADI, ALIREZA, & MASSARRAT, SADEGH. (2013). ARE THE SERUM BIOMARKERS PEPSINOGEN I AND II GOOD PREDICTORS FOR THE DETECTION OF SUBJECTS WITH ATROPHIC GASTRITIS IN AREAS THAT HAVE DIFFERENT GASTRIC CANCER INCIDENCE?. ARCHIVES OF IRANIAN MEDICINE, 16(4), 208-212. SID. https://sid.ir/paper/280947/en

Vancouver: Copy

MOHAMADKHANI ASHRAF, MOGHADAM SODAIF DARVISH, SALMANROGHANI HASAN, ALLAF ASGHARI AMIN, YAZDANBOD ABBAS, MIRZAEI MAHBOUBEH, HAJ SHEYKHOLESLAMI ARGHAVAN, BASHIRI JAFAR, SADJADI ALIREZA, MASSARRAT SADEGH. ARE THE SERUM BIOMARKERS PEPSINOGEN I AND II GOOD PREDICTORS FOR THE DETECTION OF SUBJECTS WITH ATROPHIC GASTRITIS IN AREAS THAT HAVE DIFFERENT GASTRIC CANCER INCIDENCE?. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2013;16(4):208-212. Available from: https://sid.ir/paper/280947/en

IEEE: Copy

ASHRAF MOHAMADKHANI, SODAIF DARVISH MOGHADAM, HASAN SALMANROGHANI, AMIN ALLAF ASGHARI, ABBAS YAZDANBOD, MAHBOUBEH MIRZAEI, ARGHAVAN HAJ SHEYKHOLESLAMI, JAFAR BASHIRI, ALIREZA SADJADI, and SADEGH MASSARRAT, “ARE THE SERUM BIOMARKERS PEPSINOGEN I AND II GOOD PREDICTORS FOR THE DETECTION OF SUBJECTS WITH ATROPHIC GASTRITIS IN AREAS THAT HAVE DIFFERENT GASTRIC CANCER INCIDENCE?,” ARCHIVES OF IRANIAN MEDICINE, vol. 16, no. 4, pp. 208–212, 2013, [Online]. Available: https://sid.ir/paper/280947/en

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