THERAPEUTIC EFFECTS, TOLERABILITY AND SAFETY OF A MULTI-STRAIN PROBIOTIC IN IRANIAN ADULTS WITH IRRITABLE BOWEL SYNDROME AND BLOATING

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JAFARI ELHAM; VAHEDI HOMAYOON; MERAT SHAHIN; MOMTAHEN SHABNAM; RIAHI AINA

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Journal Paper

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2014 | Volume:17 | Issue:7 Page(s): 466-470

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Title

THERAPEUTIC EFFECTS, TOLERABILITY AND SAFETY OF A MULTI-STRAIN PROBIOTIC IN IRANIAN ADULTS WITH IRRITABLE BOWEL SYNDROME AND BLOATING

Author(s)

Keywords

ADULTS

BLOATING

IBS

IRAN

PROBIOTIC

Abstract

Background: Irritable bowel syndrome (IBS) is a common disorder in IRAN with challenging treatment. Although trials have suggested that PROBIOTICs alleviate the complaints of patients with minimal side effects, they have not been investigated in IRANian ADULTS.Methods: In a randomized double-blind study, 108 eligible IBS patients (Rome III Criteria) aged 20 – 70 years who referred consecutively to a clinical center in Tehran with abdominal BLOATING from 2010 to 2012 received a combination PROBIOTICs or placebo twice Daily for 4 weeks. The objective was to evaluate the efficacy and safety of a multi-strain PROBIOTIC combination. One week prior and throughout the treatment, the participants recorded their abdominal symptoms on a daily basis, using visual analogue scale and reported satisfactory relief of general symptoms at the end of each week. Adverse events were evaluated by self-reporting and physical examination. Continuous variables were analyzed by independent t-test and chi-square was used for binomials.Results: The baseline characteristics were balanced (60% female, mean age 36.7±11.5). A total of 97 (51 intervention, 46 control) completed the treatment. Intention to treat analysis was done on 108 allocated subjects. 85% of the PROBIOTIC group reported satisfactory relief of general symptoms compared with 47% in the control group (P<0.01). A reduction in abdominal BLOATING and pain with PROBIOTIC was superior to placebo [-13.0 vs. -3.7 (P<0.01), -8.2 vs. -2.1 (P=0.02), respectively]. No severe adverse drug reaction was seen in either group. Conclusions: A 4-week period of treatment with the combination PROBIOTICs twice daily was safe, well tolerated, and effective in our patients. Further investigation is recommended for other subgroups of IBS. Trial Registration: IRCT.ir IRCT2012071010230N1

Cites

A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF LACTOBACILLUS REUTERI FOR CHRONIC FUNCTIONAL ABDOMINAL PAIN IN CHILDREN

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APA: Copy

JAFARI, ELHAM, VAHEDI, HOMAYOON, MERAT, SHAHIN, MOMTAHEN, SHABNAM, & RIAHI, AINA. (2014). THERAPEUTIC EFFECTS, TOLERABILITY AND SAFETY OF A MULTI-STRAIN PROBIOTIC IN IRANIAN ADULTS WITH IRRITABLE BOWEL SYNDROME AND BLOATING. ARCHIVES OF IRANIAN MEDICINE, 17(7), 466-470. SID. https://sid.ir/paper/280989/en

Vancouver: Copy

JAFARI ELHAM, VAHEDI HOMAYOON, MERAT SHAHIN, MOMTAHEN SHABNAM, RIAHI AINA. THERAPEUTIC EFFECTS, TOLERABILITY AND SAFETY OF A MULTI-STRAIN PROBIOTIC IN IRANIAN ADULTS WITH IRRITABLE BOWEL SYNDROME AND BLOATING. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2014;17(7):466-470. Available from: https://sid.ir/paper/280989/en

IEEE: Copy

ELHAM JAFARI, HOMAYOON VAHEDI, SHAHIN MERAT, SHABNAM MOMTAHEN, and AINA RIAHI, “THERAPEUTIC EFFECTS, TOLERABILITY AND SAFETY OF A MULTI-STRAIN PROBIOTIC IN IRANIAN ADULTS WITH IRRITABLE BOWEL SYNDROME AND BLOATING,” ARCHIVES OF IRANIAN MEDICINE, vol. 17, no. 7, pp. 466–470, 2014, [Online]. Available: https://sid.ir/paper/280989/en

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