ASSOCIATION OF THE 223A/G LEPR POLYMORPHISM WITH SERUM LEPTIN LEVELS IN IRANIAN SUBJECTS WITH TYPE 2 DIABETES

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MOHAMMADZADEH GHORBAN; NIKZAMIR ABDOLRAHIM; MOHAMMADI JAVAD; POURDASHTI SARA; SHABAZIAN HAJEH; LATIFI SEYED MAHMOUD

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2013 | Volume:16 | Issue:11 Page(s): 636-641

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Title

ASSOCIATION OF THE 223A/G LEPR POLYMORPHISM WITH SERUM LEPTIN LEVELS IN IRANIAN SUBJECTS WITH TYPE 2 DIABETES

Author(s)

Keywords

LEPR

PCR-RFLP

T2DM

Abstract

BACKGROUND: Leptin, an adipocyte-derived hormone, has a pivotal role in the regulation of body weight through acting on its specific leptin receptor (LEPR). The 223A/G polymorphism of the LEPR gene is one of the most common polymorphism in all populations. In this study, we aimed to investigate the impact of the 223A/G polymorphism of the LEPR gene on serum levels of leptin in type 2 diabetes mellitus (T2DM) in a sample of Iranian population.MATERIALS AND METHODS: One hundred and forty-four T2DM patients were screened and compared to 147 healthy controls. The 223A/G LEPR polymorphism was genotyped using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). The serum levels of leptin were measured. RESULTS: The mean serum levels of leptin in T2DM patients were significantly higher than that of healthy control subjects; 22.90 ng/ml (95% confidence interval [CI]=20.79 – 25.23) vs. 8.70 ng/ml (95% CI=7.87 – 9.63). The genotypes (AA, AG, and GG) distributions of the 223A/G polymorphism were 55.5%, 41%, and 3.5% in T2DM and 54.4%, 42.2%, and 3.4% in healthy controls. The results showed no significant differences in the 223A/G LEPR genotype and allele frequencies between T2DM and control subjects (X2=0.043, P=0.979 and X2=0.003, P=0.957), respectively. In addition, the serum leptin levels were markedly higher in subjects with GG genotype than those with AG or GG genotype only in T2DM CONCLUSION: The 223A/G LEPR gene polymorphism is associated with markedly increased serum leptin levels in T2DM. However, no differences were determined in genotype and allele frequencies between T2DM patients and control subjects.

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APA: Copy

MOHAMMADZADEH, GHORBAN, NIKZAMIR, ABDOLRAHIM, MOHAMMADI, JAVAD, POURDASHTI, SARA, SHABAZIAN, HAJEH, & LATIFI, SEYED MAHMOUD. (2013). ASSOCIATION OF THE 223A/G LEPR POLYMORPHISM WITH SERUM LEPTIN LEVELS IN IRANIAN SUBJECTS WITH TYPE 2 DIABETES. ARCHIVES OF IRANIAN MEDICINE, 16(11), 636-641. SID. https://sid.ir/paper/281104/en

Vancouver: Copy

MOHAMMADZADEH GHORBAN, NIKZAMIR ABDOLRAHIM, MOHAMMADI JAVAD, POURDASHTI SARA, SHABAZIAN HAJEH, LATIFI SEYED MAHMOUD. ASSOCIATION OF THE 223A/G LEPR POLYMORPHISM WITH SERUM LEPTIN LEVELS IN IRANIAN SUBJECTS WITH TYPE 2 DIABETES. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2013;16(11):636-641. Available from: https://sid.ir/paper/281104/en

IEEE: Copy

GHORBAN MOHAMMADZADEH, ABDOLRAHIM NIKZAMIR, JAVAD MOHAMMADI, SARA POURDASHTI, HAJEH SHABAZIAN, and SEYED MAHMOUD LATIFI, “ASSOCIATION OF THE 223A/G LEPR POLYMORPHISM WITH SERUM LEPTIN LEVELS IN IRANIAN SUBJECTS WITH TYPE 2 DIABETES,” ARCHIVES OF IRANIAN MEDICINE, vol. 16, no. 11, pp. 636–641, 2013, [Online]. Available: https://sid.ir/paper/281104/en

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