مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

362
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

194
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

GENETIC VARIABILITY OF CYP2B6 POLYMORPHISMS IN SOUTHEAST IRANIAN POPULATION: IMPLICATIONS FOR MALARIA AND HIV/AIDS TREATMENT

Pages

  685-691

Abstract

 BACKGROUND: GENETIC POLYMORPHISMS in the CYTOCHROME P450 2B6 (CYP2B6) gene could influence therapeutic outcomes of CYP2B6-metabolized drugs such as artemisinin, nevirapine (NVP), and efavirenz (EFV). The main objective of the present study was to analyze the frequency of the most common allele of CYP2B6*1 to *7 and *9 in Iranian Baluchi population and also to compare the frequencies of these polymorphisms with those reported in different ethnic groups.METHODS: A total of 206 healthy, unrelated, subjects were participated in this study. CYP2B6*1, *2, *3, *4, *5, *6,*7, and *9 polymorphisms were investigated, using PCR-RFLP followed by sequencing analysis.RESULTS: High frequency of 516T (35.7%) was found among the studied subjects. Also, the three most frequent genotypes were CYP2B6*1/*6 (28.1%), CYP2B6*1/*1 (16%) and CYP2B6*1/*9 (14.6%). The frequency of CYP2B6*6/*6 (4.8%) was not different from Caucasian, Japanese and Chinese populations, but it was lower than West African (17%) and Papua New Guinean (43%) populations. CONCLUSION: Allele frequencies for CYP2B6 in the examined population were markedly different from those African, Caucasian, and Southeast Asian populations. CYP2B6*2, *4, *5, *6, and *7 were found in the Iranian Baluchi that may affect the response to artemisin and its derivatives. High frequency of G516T (35.7%) was detected among the examined subjects that might cause greater efavirenz plasma exposure and more central nervous system side effects. Therefore, characterization of pharmacologically relevant polymorphisms in CYP2B6 has a great potential to improve drug efficacy and reduce toxicity.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ZAKERI, SEDIGHEH, AMIRI, NASRIN, PIRAHMADI, SAKINEH, & DINPARAST DJADID, NAVID. (2014). GENETIC VARIABILITY OF CYP2B6 POLYMORPHISMS IN SOUTHEAST IRANIAN POPULATION: IMPLICATIONS FOR MALARIA AND HIV/AIDS TREATMENT. ARCHIVES OF IRANIAN MEDICINE, 17(10), 685-691. SID. https://sid.ir/paper/281119/en

    Vancouver: Copy

    ZAKERI SEDIGHEH, AMIRI NASRIN, PIRAHMADI SAKINEH, DINPARAST DJADID NAVID. GENETIC VARIABILITY OF CYP2B6 POLYMORPHISMS IN SOUTHEAST IRANIAN POPULATION: IMPLICATIONS FOR MALARIA AND HIV/AIDS TREATMENT. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2014;17(10):685-691. Available from: https://sid.ir/paper/281119/en

    IEEE: Copy

    SEDIGHEH ZAKERI, NASRIN AMIRI, SAKINEH PIRAHMADI, and NAVID DINPARAST DJADID, “GENETIC VARIABILITY OF CYP2B6 POLYMORPHISMS IN SOUTHEAST IRANIAN POPULATION: IMPLICATIONS FOR MALARIA AND HIV/AIDS TREATMENT,” ARCHIVES OF IRANIAN MEDICINE, vol. 17, no. 10, pp. 685–691, 2014, [Online]. Available: https://sid.ir/paper/281119/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button