PRENATAL DIAGNOSIS OF β-THALASSEMIA IN TWIN PREGNANCIES IN IRAN

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KAINIMOGHADDAM ZAHRA; VALAEI ATEFEH; BAYAT FATEMEH; TAGHAVI BASMANJ MARYAM; NAVABMOGHADDAM FATEMEH; MORTEZAZADEH MARJANALSADAT; TEIMOORI TOOLABI LADAN; AHMADI SETAREH; SADEGH SHAGHAYEGH; KORDAFSHARI ALIREZA; KARIMIPOOR MORTEZA; ZEINALI SIROUS

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2013 | Volume:16 | Issue:10 Page(s): 573-575

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Title

PRENATAL DIAGNOSIS OF β-THALASSEMIA IN TWIN PREGNANCIES IN IRAN

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Keywords

β-THALASSEMIA

PRENATAL DIAGNOSIS

RFLP

TWINS

Abstract

OBJECTIVE: PRENATAL DIAGNOSIS of b-thalassemia carrier couples has helped to prevent bearing affected children. Among 177 couples referred to our laboratory for PRENATAL DIAGNOSIS, 14 mothers had twin pregnancies. METHODS: By using direct and indirect methods, we determined their mutations and linkage analysis using polymorphic markers (restriction fragment length polymorphism [RFLP]). RESULTS: It was shown that in five families both fetuses were heterozygote carriers. In another five families, one fetus was normal and the other one was carrier. In two families, one fetus was affected and the other one was heterozygous carrier; in one case one fetus was affected and the other one was homozygote normal. In the last family both fetuses were homozygote normal. If all fetuses were fraternal then one would expect to see seven homozygote normal and the same number affected, and 14 carriers.CONCLUSION: Our results indicated that at least in cases where both fetuses had identical genotypes, then they may be identical TWINS. Molecular testing indeed showed that in three cases the TWINS were identical.Another point is that in three cases, one of the twin fetuses was affected and the other one was either normal or heterozygote in which only the affected fetuses were aborted by the specialist.

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APA: Copy

KAINIMOGHADDAM, ZAHRA, VALAEI, ATEFEH, BAYAT, FATEMEH, TAGHAVI BASMANJ, MARYAM, NAVABMOGHADDAM, FATEMEH, MORTEZAZADEH, MARJANALSADAT, TEIMOORI TOOLABI, LADAN, AHMADI, SETAREH, SADEGH, SHAGHAYEGH, KORDAFSHARI, ALIREZA, KARIMIPOOR, MORTEZA, & ZEINALI, SIROUS. (2013). PRENATAL DIAGNOSIS OF β-THALASSEMIA IN TWIN PREGNANCIES IN IRAN. ARCHIVES OF IRANIAN MEDICINE, 16(10), 573-575. SID. https://sid.ir/paper/281150/en

Vancouver: Copy

KAINIMOGHADDAM ZAHRA, VALAEI ATEFEH, BAYAT FATEMEH, TAGHAVI BASMANJ MARYAM, NAVABMOGHADDAM FATEMEH, MORTEZAZADEH MARJANALSADAT, TEIMOORI TOOLABI LADAN, AHMADI SETAREH, SADEGH SHAGHAYEGH, KORDAFSHARI ALIREZA, KARIMIPOOR MORTEZA, ZEINALI SIROUS. PRENATAL DIAGNOSIS OF β-THALASSEMIA IN TWIN PREGNANCIES IN IRAN. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2013;16(10):573-575. Available from: https://sid.ir/paper/281150/en

IEEE: Copy

ZAHRA KAINIMOGHADDAM, ATEFEH VALAEI, FATEMEH BAYAT, MARYAM TAGHAVI BASMANJ, FATEMEH NAVABMOGHADDAM, MARJANALSADAT MORTEZAZADEH, LADAN TEIMOORI TOOLABI, SETAREH AHMADI, SHAGHAYEGH SADEGH, ALIREZA KORDAFSHARI, MORTEZA KARIMIPOOR, and SIROUS ZEINALI, “PRENATAL DIAGNOSIS OF β-THALASSEMIA IN TWIN PREGNANCIES IN IRAN,” ARCHIVES OF IRANIAN MEDICINE, vol. 16, no. 10, pp. 573–575, 2013, [Online]. Available: https://sid.ir/paper/281150/en

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