EFFECT OF INTRA-AMYGDALA INJECTION OF LIPOPOLYSACCHARIDE ON KINDLING EPILEPTOGENESIS IN ADULT RATS

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AKHLAGHI ZHAMAK; SAYAH MOHAMMAD; MOKHTARI MEHRDAD; AHMADI AMIN

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2012 | Volume:15 | Issue:9 Page(s): 557-559

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Information Journal Paper

Title

EFFECT OF INTRA-AMYGDALA INJECTION OF LIPOPOLYSACCHARIDE ON KINDLING EPILEPTOGENESIS IN ADULT RATS

Author(s)

AKHLAGHI ZHAMAK | SAYAH MOHAMMAD | MOKHTARI MEHRDAD | AHMADI AMIN | Issue Writer Certificate

Keywords

AMYGDALA

EPILEPTOGENESIS

LIPOPOLYSACCHARIDE

Abstract

BACKGROUND: Contribution of neuroinflammation and epilepsy in the mature brain has elicited contradictory results with either excitatory or inhibitory effects. The AMYGDALA is one of the main parts of the limbic system susceptible to insults that lead to neuroinflammation and epilepsy. This study evaluates the effect of chronic inflammation of the rat AMYGDALA induced by LIPOPOLYSACCHARIDE (LPS) on kindling EPILEPTOGENESIS.METHODS: LPS (5mg/rat) was infused once daily into the basolateral AMYGDALA (BLA) of adult rats. Daily electrical stimulation (150-300 mA, 100 Hz, monophasic square wave stimulus of 1 msec per wave, 2 sec duration) was delivered into BLA 30 min after LPS injections until the animals became fully kindled.RESULTS: LPS had no significant effect on the development of focal and generalized seizures.CONCLUSION: The type of neural system exposed to LPS and its specific electrophysiological properties seems to ascertain the final excitatory or inhibitory outcome.

Cites

Cognitive Functions in Epileptic Patients on Lamotrigine and Other Antiepileptic Drugs

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APA: Copy

AKHLAGHI, ZHAMAK, SAYAH, MOHAMMAD, MOKHTARI, MEHRDAD, & AHMADI, AMIN. (2012). EFFECT OF INTRA-AMYGDALA INJECTION OF LIPOPOLYSACCHARIDE ON KINDLING EPILEPTOGENESIS IN ADULT RATS. ARCHIVES OF IRANIAN MEDICINE, 15(9), 557-559. SID. https://sid.ir/paper/281184/en

Vancouver: Copy

AKHLAGHI ZHAMAK, SAYAH MOHAMMAD, MOKHTARI MEHRDAD, AHMADI AMIN. EFFECT OF INTRA-AMYGDALA INJECTION OF LIPOPOLYSACCHARIDE ON KINDLING EPILEPTOGENESIS IN ADULT RATS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2012;15(9):557-559. Available from: https://sid.ir/paper/281184/en

IEEE: Copy

ZHAMAK AKHLAGHI, MOHAMMAD SAYAH, MEHRDAD MOKHTARI, and AMIN AHMADI, “EFFECT OF INTRA-AMYGDALA INJECTION OF LIPOPOLYSACCHARIDE ON KINDLING EPILEPTOGENESIS IN ADULT RATS,” ARCHIVES OF IRANIAN MEDICINE, vol. 15, no. 9, pp. 557–559, 2012, [Online]. Available: https://sid.ir/paper/281184/en

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