مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

ELEVATED SERUM VISFATIN LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Pages

  688-692

Abstract

 BACKGROUND: Visfatin, a novel adiopocytokine, has been proven to be a PROINFLAMMATORY mediator involved in the process of ATHEROSCLEROSIS. Visfatin has been shown to play a role in plaque destabilization as it is found abundantly in foam cell macrophages within unstable atherosclerotic plaques. The present study is designed to investigate the potential association between serum vistafin levels and the risk of acute myocardial infarction (AMI).METHODS: There were 72 patients (mean age: 61.57±11.40 years) as cases who presented with first-time AMI that were assessed 8 hours after the incident. The control group consisted of 83 healthy volunteers (mean age: 60.30±8.32 years). Plasma visfatin levels were measured using enzyme immunoassay in both groups. Biochemical parameters were analyzed. Blood pressure, body mass index (BMI), waist circumference, diabetes, and hypertension were recorded.RESULTS: Serum visfatin levels were significantly higher in patients with AMI (12.77±8.06 ng/ml) compared to controls (6.57±2.96 ng/ml, P≤0.001). We found that a visfatin level >7.244 ng/ml (log visfatin > 0.86) had a sensitivity of 70% and a specificity of 75% for predicting AMI.CONCLUSION: We have detected high levels of visfatin in patients with AMI. It can be concluded that PROINFLAMMATORY CYTOKINES such as visfatin may play a role in the development of ATHEROSCLEROSIS as well as destabilization of the atherosclerotic plaque.

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    APA: Copy

    MAZAHERIOUN, MARYAM, HOSSEINZADEH ATTAR, MOHAMMAD JAVAD, JANANI, LEILA, VASHEGHANI FARAHANI, ALI, REZVAN, NEDA, KARBASCHIAN, ZOHREH, & HOSSEIN NEZHAD, ARASH. (2012). ELEVATED SERUM VISFATIN LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. ARCHIVES OF IRANIAN MEDICINE, 15(11), 688-692. SID. https://sid.ir/paper/281220/en

    Vancouver: Copy

    MAZAHERIOUN MARYAM, HOSSEINZADEH ATTAR MOHAMMAD JAVAD, JANANI LEILA, VASHEGHANI FARAHANI ALI, REZVAN NEDA, KARBASCHIAN ZOHREH, HOSSEIN NEZHAD ARASH. ELEVATED SERUM VISFATIN LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2012;15(11):688-692. Available from: https://sid.ir/paper/281220/en

    IEEE: Copy

    MARYAM MAZAHERIOUN, MOHAMMAD JAVAD HOSSEINZADEH ATTAR, LEILA JANANI, ALI VASHEGHANI FARAHANI, NEDA REZVAN, ZOHREH KARBASCHIAN, and ARASH HOSSEIN NEZHAD, “ELEVATED SERUM VISFATIN LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION,” ARCHIVES OF IRANIAN MEDICINE, vol. 15, no. 11, pp. 688–692, 2012, [Online]. Available: https://sid.ir/paper/281220/en

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