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Information Journal Paper

Title

PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA)

Pages

  426-429

Abstract

 BACKGROUND: This study was designed to evaluate PLATELET TRANSFUSION outcome via flow cytometric monocyte phagocytic assay (FMPA).METHODS: Fifteen patients with a history of multiple PLATELET TRANSFUSIONs and fifteen controls were enrolled in this study. CMFDA-labeled platelets were incubated with patients' sera and were finally incubated with monocytes in a tube and analyzed by FLOW CYTOMETRY. Monocytes that phagocytosed platelets were detected as a CMFDA-positive platelet population via monocyte gate. The FMPA results were compared with CCI results for the patients.RESULTS: The FMPA result correlated with 1-hour (r=-0.885, P=0.001) and 24-hour (r=-0.884, P=0.001) CCI. There is a significant difference in means of FMPA results between the patients with immune platelet refractoriness (68.46±10.4%), non-refractory group (37.73±15.21%) and the control group (18.27±2.86%). CONCLUSION: Our data showed that FMPA has good results in evaluation of PLATELET TRANSFUSION outcome and may be useful as an indicator of PLATELET TRANSFUSION response.

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    APA: Copy

    SAYYADI, MOHAMMAD, SHAIEGAN, MOJGAN, NIKOUGOFTAR ZARIF, MAHIN, VAEZI, MOHAMMAD, & MOHAMMADI, SAEED. (2016). PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA). ARCHIVES OF IRANIAN MEDICINE, 19(6), 426-429. SID. https://sid.ir/paper/281375/en

    Vancouver: Copy

    SAYYADI MOHAMMAD, SHAIEGAN MOJGAN, NIKOUGOFTAR ZARIF MAHIN, VAEZI MOHAMMAD, MOHAMMADI SAEED. PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA). ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(6):426-429. Available from: https://sid.ir/paper/281375/en

    IEEE: Copy

    MOHAMMAD SAYYADI, MOJGAN SHAIEGAN, MAHIN NIKOUGOFTAR ZARIF, MOHAMMAD VAEZI, and SAEED MOHAMMADI, “PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA),” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 6, pp. 426–429, 2016, [Online]. Available: https://sid.ir/paper/281375/en

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