REVIEW ARTICLE: GENETIC STUDIES IN INTELLECTUAL DISABILITY AND BEHAVIORAL IMPAIRMENT

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MEHREGAN HODA; NAJMABADI HOSSEIN; KAHRIZI KIMIA

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Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2016 | Volume:19 | Issue:5 Page(s): 363-375

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Information Journal Paper

Title

REVIEW ARTICLE: GENETIC STUDIES IN INTELLECTUAL DISABILITY AND BEHAVIORAL IMPAIRMENT

Author(s)

MEHREGAN HODA | NAJMABADI HOSSEIN | KAHRIZI KIMIA | Issue Writer Certificate

Keywords

BEHAVIORAL IMPAIRMENT

DISORDER

GENES

INTELLECTUAL DISABILITY

Abstract

Intellectual Disability (ID, also known as mental retardation) is a debilitating neurodevelopmental DISORDER affecting nearly 1% of the general population worldwide. Occurrence of behavioral DISORDERs in individuals with ID is four times higher than that in the general population. An increasing number of studies seek to find a common pathway to elucidate brain structure/function and its contribution to behavior. This article deals with different behavioral DISORDERs reported in individuals with syndromic and non-syndromic ID and possible candidate GENES, most of which are involved in synaptic formation and function. Many ID cases with behavior impairments were referred to genetic centers to identify genetic causes; therefore, the authors gathered data from their own studies along with similar published reports, to provide a review on GENES involved in brain development and cognition. In this study, we argued how defects in GENES with diverse functional role may contribute to behavior impairments and a brain malfunction. Evidences from individual with cognitive impairment as well as murine and drosophila animal models have been used to show behavioral consequences of functional deficits in GENES speculated to play a role in cognition and learning.

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APA: Copy

MEHREGAN, HODA, NAJMABADI, HOSSEIN, & KAHRIZI, KIMIA. (2016). REVIEW ARTICLE: GENETIC STUDIES IN INTELLECTUAL DISABILITY AND BEHAVIORAL IMPAIRMENT. ARCHIVES OF IRANIAN MEDICINE, 19(5), 363-375. SID. https://sid.ir/paper/281423/en

Vancouver: Copy

MEHREGAN HODA, NAJMABADI HOSSEIN, KAHRIZI KIMIA. REVIEW ARTICLE: GENETIC STUDIES IN INTELLECTUAL DISABILITY AND BEHAVIORAL IMPAIRMENT. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(5):363-375. Available from: https://sid.ir/paper/281423/en

IEEE: Copy

HODA MEHREGAN, HOSSEIN NAJMABADI, and KIMIA KAHRIZI, “REVIEW ARTICLE: GENETIC STUDIES IN INTELLECTUAL DISABILITY AND BEHAVIORAL IMPAIRMENT,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 5, pp. 363–375, 2016, [Online]. Available: https://sid.ir/paper/281423/en

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