Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat

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Keramati Nojedehsadat Marzieh; ORYAN SHAHRBANOO; ZARRINDAST MOHAMMAD REZA; BABAPOUR VAHAB

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2017 | Volume:20 | Issue:3 Page(s): 185-192

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Title

Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat

Author(s)

Keramati Nojedehsadat Marzieh | ORYAN SHAHRBANOO | ZARRINDAST MOHAMMAD REZA | BABAPOUR VAHAB | Issue Writer Certificate

Keywords

Accumbens shell

ACPA

aversive memory

HT1 receptors agonist and antagonist

Abstract

BACKGROUND: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of Accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats. METHOD: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 HCL (5-HT1 receptor agonist agonist) or GR127935 HCL (5-HT1 receptor antagonist). RESULTS: Post-test intra-Acb shell of ACPA (0. 002 μ g/rat), CP94253 (0. 5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day. CONCLUSION: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell.

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APA: Copy

Keramati Nojedehsadat, Marzieh, ORYAN, SHAHRBANOO, ZARRINDAST, MOHAMMAD REZA, & BABAPOUR, VAHAB. (2017). Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat. ARCHIVES OF IRANIAN MEDICINE, 20(3), 185-192. SID. https://sid.ir/paper/281472/en

Vancouver: Copy

Keramati Nojedehsadat Marzieh, ORYAN SHAHRBANOO, ZARRINDAST MOHAMMAD REZA, BABAPOUR VAHAB. Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2017;20(3):185-192. Available from: https://sid.ir/paper/281472/en

IEEE: Copy

Marzieh Keramati Nojedehsadat, SHAHRBANOO ORYAN, MOHAMMAD REZA ZARRINDAST, and VAHAB BABAPOUR, “Activation and Deactivation of 5-HT1 Receptor of Accumbens Shell Area does not Alter ACPA-induced Aversive Memory Deficit in Male Rat,” ARCHIVES OF IRANIAN MEDICINE, vol. 20, no. 3, pp. 185–192, 2017, [Online]. Available: https://sid.ir/paper/281472/en

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