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Information Journal Paper

Title

HELICOBACTER PYLORI MULTIDRUG RESISTANCE DUE TO MISUSE OF ANTIBIOTICS IN IRAN

Pages

  283-288

Abstract

 Background: Helicobacter pylori might become highly resistant to antibiotics taken through the life time of patients. This study examined the change in ANTIBIOTIC RESISTANCE of H. pylori by time. Methods: Out of 985 dyspeptic patients who were referred to the endoscopy unit of Shariati hospital during 2010-2017, 218 patients with gastric biopsies positive for rapid urease test (RUT) and H. pylori culture were recruited in the study. H. pylori isolates were examined for resistance to 8 currently used antibiotics by the disc diffusion method. Results were compared with those from our three previous studies. The frequency of multidrug resistance (MDR) was also assessed. Results: The highest resistance rate was to metronidazole (MTZ) (79. 4%) followed by ofloxacin (OFX) (58. 7%), ciprofloxacin (CIP) (46. 8%), levofloxacin (LVX) (45%), tetracycline (TET) (38. 5%), clarithromycin (CLR) (34. 4%), amoxicillin (AMX) (27. 1%) and furazolidone (FRZ) (23. 9%). No significant difference was found between resistance of H. pylori isolates from male and female <40 and >40 years old and patients with gastritis and peptic ulcer. The highest rates of MDR were to MTZ+OFX (4. 6%), MTZ+OFX+TET (2. 8%), MTZ+OFX+CIP+LVX (6. 4%) and MTZ+OFX+TET+ CIP+LVX (5%). Conclusion: Resistance to MTZ increased from 33%– 55. 6% in previous studies to 79. 4% by time, to CLR increased from 1. 4– 7. 3% to 34. 4%, to TET increased from 0– 38. 1% to 38. 5%, to AMX increased from 1. 4%– 7. 3% to 27. 1% and to FRZ increased from 0%– 4. 5% to 23. 9%. Resistance to FQs was 45%– 58. 7%. Increase in H. pylori ANTIBIOTIC RESISTANCE indicates antibiotic MISUSE. In Iran, with a considerable number of H. pylori-infected patients, antibiotic therapy should be saved for high risk patients and according to local ANTIBIOTIC RESISTANCE patterns.

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    • Cite

    APA: Copy

    SANIEE, PARASTOO, HOSSEINI, FARIDEH, KADKHODAEI, SARA, SIAVOSHI, FARIDEH, & KHALILI SAMANI, SAMAN. (2018). HELICOBACTER PYLORI MULTIDRUG RESISTANCE DUE TO MISUSE OF ANTIBIOTICS IN IRAN. ARCHIVES OF IRANIAN MEDICINE, 21(7), 283-288. SID. https://sid.ir/paper/281545/en

    Vancouver: Copy

    SANIEE PARASTOO, HOSSEINI FARIDEH, KADKHODAEI SARA, SIAVOSHI FARIDEH, KHALILI SAMANI SAMAN. HELICOBACTER PYLORI MULTIDRUG RESISTANCE DUE TO MISUSE OF ANTIBIOTICS IN IRAN. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(7):283-288. Available from: https://sid.ir/paper/281545/en

    IEEE: Copy

    PARASTOO SANIEE, FARIDEH HOSSEINI, SARA KADKHODAEI, FARIDEH SIAVOSHI, and SAMAN KHALILI SAMANI, “HELICOBACTER PYLORI MULTIDRUG RESISTANCE DUE TO MISUSE OF ANTIBIOTICS IN IRAN,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 7, pp. 283–288, 2018, [Online]. Available: https://sid.ir/paper/281545/en

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