THE EFFECTS OF PROBIOTIC SUPPLEMENTATION ON GENE EXPRESSION RELATED TO INFLAMMATION, INSULIN AND LIPID IN PATIENTS WITH PARKINSON’ S DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

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BORZABADI SHOKOOFEH; ORYAN SHAHRBANOO; EIDI AKRAM; Aghadavod Esmat; DANESHVAR KAKHAKI REZA; TAMTAJI OMID REZA; TAGHIZADEH MOHSEN; ASEMI ZATOLLAH

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2018 | Volume:21 | Issue:7 Page(s): 289-295

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Title

THE EFFECTS OF PROBIOTIC SUPPLEMENTATION ON GENE EXPRESSION RELATED TO INFLAMMATION, INSULIN AND LIPID IN PATIENTS WITH PARKINSON’ S DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

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Keywords

INFLAMMATION

INSULIN METABOLISM

PARKINSON’S DISEASE

PROBIOTICS SUPPLEMENTATION

Abstract

Background: This study was conducted to evaluate the effects of probiotic supplementation on gene expression related to INFLAMMATION, insulin and lipid in patients with Parkinson’ s disease (PD). Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted in 50 patients with PD as a pilot study. Participants were randomly allocated into two groups to take either 8×109 CFU/day probiotic supplements or placebo (n = 25 each group, one capsule daily) for 12 weeks. Gene expression related to INFLAMMATION, insulin, and lipid was quantified in peripheral blood mononuclear cells (PBMC) of PD patients, with RT-PCR method. Results: After the 12-week intervention, compared with the placebo, probiotic intake downregulated gene expression of interleukin-1 (IL-1) (P = 0. 03), IL-8 (P < 0. 001) and tumor necrosis factor alpha (TNF-α ) (P=0. 04) in PBMC of subjects with PD. In addition, probiotic supplementation upregulated transforming growth factor beta (TGF-β ) (P = 0. 02) and peroxisome proliferator-activated receptor gamma (PPAR-γ ) (P = 0. 03) in PBMC of subjects with PD compared with the placebo. We did not observe any significant effect of probiotic intake on gene expression of low-density lipoprotein receptor (LDLR) and vascular endothelial growth factor (VEGF) in PBMC of patients with PD. Conclusion: Overall, PROBIOTICS SUPPLEMENTATION for 12 weeks in PD patients significantly improved gene expression of IL-1, IL-8, TNF-α , TGF-β and PPAR-γ , but did not affect gene expression of VEGF and LDLR, and biomarkers of INFLAMMATION and oxidative stress.

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APA: Copy

BORZABADI, SHOKOOFEH, ORYAN, SHAHRBANOO, EIDI, AKRAM, Aghadavod, Esmat, DANESHVAR KAKHAKI, REZA, TAMTAJI, OMID REZA, TAGHIZADEH, MOHSEN, & ASEMI, ZATOLLAH. (2018). THE EFFECTS OF PROBIOTIC SUPPLEMENTATION ON GENE EXPRESSION RELATED TO INFLAMMATION, INSULIN AND LIPID IN PATIENTS WITH PARKINSON’ S DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. ARCHIVES OF IRANIAN MEDICINE, 21(7), 289-295. SID. https://sid.ir/paper/281548/en

Vancouver: Copy

BORZABADI SHOKOOFEH, ORYAN SHAHRBANOO, EIDI AKRAM, Aghadavod Esmat, DANESHVAR KAKHAKI REZA, TAMTAJI OMID REZA, TAGHIZADEH MOHSEN, ASEMI ZATOLLAH. THE EFFECTS OF PROBIOTIC SUPPLEMENTATION ON GENE EXPRESSION RELATED TO INFLAMMATION, INSULIN AND LIPID IN PATIENTS WITH PARKINSON’ S DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(7):289-295. Available from: https://sid.ir/paper/281548/en

IEEE: Copy

SHOKOOFEH BORZABADI, SHAHRBANOO ORYAN, AKRAM EIDI, Esmat Aghadavod, REZA DANESHVAR KAKHAKI, OMID REZA TAMTAJI, MOHSEN TAGHIZADEH, and ZATOLLAH ASEMI, “THE EFFECTS OF PROBIOTIC SUPPLEMENTATION ON GENE EXPRESSION RELATED TO INFLAMMATION, INSULIN AND LIPID IN PATIENTS WITH PARKINSON’ S DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 7, pp. 289–295, 2018, [Online]. Available: https://sid.ir/paper/281548/en

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