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Information Journal Paper

Title

RETROSPECTIVE ANALYSIS OF 345 MULTIPLE MYELOMA CASES: AN INVESTIGATION FROM 2 INSTITUTIONS

Pages

  412-417

Abstract

 Background: MULTIPLE MYELOMA (MM) accounts for a substantial mortality rate among hematological cancers. The prognosis of the disease has been noticeably changed during the past 2 decades. This study reports a retrospective analysis of 345 MM cases from 2 cancer centers. Methods: Medical records of 345 MM cases were analyzed in retrospect. Diagnosis of MM was defined in presence of at least 10% plasma cells in bone marrow biopsy and one of the CRAB findings (hypercalcemia, renal failure, anemia and myeloma bone lesions). Survival analysis was performed using Kaplan-Meier method, and the effects of prognostic variables were assessed by Cox proportional hazards model. Results: The mean age of the patients was 61. 98 ± 11. 44 years. Comparing to Mayo Clinic series, our patients were relatively younger and suffered from more advanced disease. By a median follow up time of 45 months, 1-and 5-year overall survival (OS) rates were 78. 0% and 35. 6%, respectively. Regarding first progression free survival (PFS1), similar rates of 57. 7% and 17. 0% were observed respectively. In multivariate analysis, hypercalcemia (corrected serum calcium >11 mg/dL), PANCYTOPENIA and elevated serum creatinine (Cr) (>2 mg/dL) were found to be independent prognostic factors affecting OS. Conclusion: Presentation of MM in Iran which is a developing country, was significantly different from developed countries. This finding might be generalized to other developing countries as well. In addition, vincristine-adriamycin-dexamethasone (VAD) therapy was an inferior protocol compared to BORTEZOMIB as first and second lines. Furthermore, PANCYTOPENIA was observed in about 9% of the patients and was an independent prognosticator of the disease.

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    APA: Copy

    JALAEIKHOO, HASAN, SHARIFZADEH, MORTEZA, RAJAEINEJAD, MOHSEN, KEYHANI, MANOUTCHEHR, & ZOKAASADI, MOHAMMAD. (2018). RETROSPECTIVE ANALYSIS OF 345 MULTIPLE MYELOMA CASES: AN INVESTIGATION FROM 2 INSTITUTIONS. ARCHIVES OF IRANIAN MEDICINE, 21(9), 412-417. SID. https://sid.ir/paper/281585/en

    Vancouver: Copy

    JALAEIKHOO HASAN, SHARIFZADEH MORTEZA, RAJAEINEJAD MOHSEN, KEYHANI MANOUTCHEHR, ZOKAASADI MOHAMMAD. RETROSPECTIVE ANALYSIS OF 345 MULTIPLE MYELOMA CASES: AN INVESTIGATION FROM 2 INSTITUTIONS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(9):412-417. Available from: https://sid.ir/paper/281585/en

    IEEE: Copy

    HASAN JALAEIKHOO, MORTEZA SHARIFZADEH, MOHSEN RAJAEINEJAD, MANOUTCHEHR KEYHANI, and MOHAMMAD ZOKAASADI, “RETROSPECTIVE ANALYSIS OF 345 MULTIPLE MYELOMA CASES: AN INVESTIGATION FROM 2 INSTITUTIONS,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 9, pp. 412–417, 2018, [Online]. Available: https://sid.ir/paper/281585/en

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