Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention

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NOZARI YOUNES; PARSA MAZIYAR; JALALI ARASH; ARIANNEJAD HAMID; SHAFIEE AKBAR

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2019 | Volume:22 | Issue:4 Page(s): 198-203

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Title

Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention

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Keywords

Coronary artery disease

Mean platelet volume

Major adverse cardiac events

Non-ST elevation myocardial infarction

Percutaneous coronary intervention

Platelet count

Abstract

Background: Mean platelet volume (MPV) has been introduced as a simple and accurate method for assessing platelet function, which can be used as a prognostic marker for cardiovascular events. We investigated whether pre-procedural MPV could predict Major adverse cardiac events (MACE) in candidates for elective Percutaneous coronary intervention (PCI). Methods: In this large retrospective cohort, we reviewed the clinical and follow-up data of 4199 candidates (mean age = 59. 9 ± 10. 3 years; female patients = 1440 [34. 3%]) for elective PCI due to unstable angina (UA) or non-ST segment elevation myocardial infarction (NSTEMI). The primary endpoint of the study was the incidence of MACE defined as in-hospital mortality, cardiac death, nonfatal MI, target lesion revascularization (TLR) or target vessel revascularization (TVR). Based on the MPV level tertiles, patients were categorized into three groups for further comparison. Results: Higher MPV was significantly associated with older age (P < 0. 001), hypertension (P < 0. 001), diabetes mellitus (P = 0. 003), history of previous CABG (P < 0. 001) and lower levels of serum triglyceride (P < 0. 001). The frequency of 1-year MACE was 176 (4. 1%) with no significant difference between the MPV tertile groups. The highest MPV tertile could significantly predict MACE in the univariable model (hazard ratio = 1. 51, 95% confidence interval: 1. 05– 2. 17; P = 0. 026). In the adjusted model, the highest MPV tertile was a borderline predictor for MACE (hazard ratio = 1. 62, 95% CI: 0. 98– 2. 68; P = 0. 057). Conclusion: High MPV was associated with cardiovascular risk factors and older age while high MPV was a borderline independent predictor for 1-year MACE in the candidates for elective PCI.

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APA: Copy

NOZARI, YOUNES, PARSA, MAZIYAR, JALALI, ARASH, ARIANNEJAD, HAMID, & SHAFIEE, AKBAR. (2019). Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention. ARCHIVES OF IRANIAN MEDICINE, 22(4), 198-203. SID. https://sid.ir/paper/281799/en

Vancouver: Copy

NOZARI YOUNES, PARSA MAZIYAR, JALALI ARASH, ARIANNEJAD HAMID, SHAFIEE AKBAR. Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2019;22(4):198-203. Available from: https://sid.ir/paper/281799/en

IEEE: Copy

YOUNES NOZARI, MAZIYAR PARSA, ARASH JALALI, HAMID ARIANNEJAD, and AKBAR SHAFIEE, “Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention,” ARCHIVES OF IRANIAN MEDICINE, vol. 22, no. 4, pp. 198–203, 2019, [Online]. Available: https://sid.ir/paper/281799/en

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